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Usage

Purine family

1H-Purine, 6-[[(2-methylphenyl)methyl]thio]is a member of the purine family Purine compounds are a group of organic compounds that contain a bicyclic ring structure with both aromatic and pyrimidine-like properties.

Sulfur atom

Contains a sulfur atom in its structure The presence of sulfur in the compound can affect its chemical reactivity, stability, and potential applications.

Derivative of 1H-purine

The compound is a derivative of 1H-purine 1H-purine is a bicyclic heterocyclic aromatic organic compound, and the compound in question has been modified to have additional functional groups.

2-methylphenylmethyl group

Presence of the 2-methylphenylmethyl group in the 6-position of the purine ring This specific functional group distinguishes the compound from other purine derivatives and may influence its chemical properties and potential applications.

Pharmaceutical research applications

May have potential applications in pharmaceutical research The compound could be useful in the development of new drugs targeting purine-related biological processes, such as those involved in DNA and RNA synthesis or cellular energy metabolism.

Upstream product

• 157930-09-1 6-Mercaptopurine 
• 89-92-9 2-methylbenzyl bromide 

Relevant academic research and scientific papers

Synthesis, anti-cancer activity and mechanism study of 6-mercapto-purine derivatives

6-mercaptopurine (6-MP) is the first active metabolite inhibitor shown to suppress cancer cells. The aim of this study is to investigate the bioactivity of 6-MP derivatives and discover new anti-cancer agents. Four 6-mercaptopurine (6-MP) derivatives were synthesized and their anti-cancer activities were analyzed. All of the compounds showed anti-proliferative effects against HepG2 and A2780 cancer cells. Among the synthesized derivatives, 6-((naphthalen-2-ylmethyl)thio)-9H-purine (NMSP) which possessing a β-naphthalene, showed better anti-cancer activity than other compounds, with an IC50 value 6.09μg/mL. NMSP could induce S phase cell cycle arrest and apoptosis in HepG2 cells. Western blot analysis indicated that NMSP induced apoptosis is mitochondria-dependent. The novel 6-MP derivative discovered in this study is a promising drug candidate to be used as an anti-cancer agent.

Synthesis, Anti-cancer Activity and Mechanism Study of 6-Mercapto-purine Derivatives

6-mercaptopurine (6-MP) is the first active metabolite inhibitor shown to suppress cancer cells. The aim of this study is to investigate the bioactivity of 6-MP derivatives and discover new anti-cancer agents. Four 6-mercaptopurine (6-MP) derivatives were synthesized and their anti-cancer activities were analyzed. All of the compounds showed anti-proliferative effects against HepG2 and A2780 cancer cells. Among the synthesized derivatives, 6-((naphthalen-2-ylmethyl)thio)-9H-purine (NMSP) which possessing a β-naphthalene, showed better anti-cancer activity than other compounds, with an IC50 value 6.09μg/mL. NMSP could induce S phase cell cycle arrest and apoptosis in HepG2 cells. Western blot analysis indicated that NMSP induced apoptosis is mitochondria-dependent. The novel 6-MP derivative discovered in this study is a promising drug candidate to be used as an anti-cancer agent.

Antimycobacterial Agents. 1. Thio Analogues of Purine

Thio analogues of purine, pyridine, and pyrimidine were prepared based on the initial activity screening of several analogues of these heterocycles against Mycobacterium tuberculosis (Mtb). Certain 6-thio-substituted purine analogues described herein showed moderate to good inhibitory activity. In particular, two purine analogues 9-(ethylcarboxymethyl)-6-(decylthio)-9H-purine (20) and 9-(ethylcarboxymethyl)-6-(dodecylthio)-9H-purine (21) exhibited MIC values of 1.56 and 0.78 μg/mL respectively against the Mtb H37Rv strain. N9-Substitution apparently enhances the antimycobacterial activity in the purine series described herein.