50703-06-5

Basic information

• Product Name: METHYL THIAZOLIDINE-2-CARBOXYLATE HYDROCHLORIDE
• Synonyms: TIMTEC-BB SBB003724;THIAZOLIDINE-2-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE;BUTTPARK 48\04-48;methyl thiazolidine-4-carboxylate hydrochloride;4-ThiazolidinecarboxylicacidmethylesterHCl;Methyl Thiazolidine-2-Carboxylate HCl;2-THIAZOLIDINECARBOXYLIC ACID METHYL ESTER;methyl 1,3-thiazolidine-4-carboxylate hydrochloride
• CAS NO: 50703-06-5
• Molecular Formula: C₅H₉NO₂S*ClH
• Molecular Weight: 183.66
• EINECS: 256-726-5
• Product Categories: Heterocyclic Compounds
• Mol File: 50703-06-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 159-163 °C (dec.)(lit.)
• Boiling Point: 238.9 °C at 760 mmHg
• Flash Point: 98.3 °C
• Appearance: /
• Vapor Pressure: 0.0413mmHg at 25°C
• BRN: 3628640
• CAS DataBase Reference: METHYL THIAZOLIDINE-2-CARBOXYLATE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL THIAZOLIDINE-2-CARBOXYLATE HYDROCHLORIDE(50703-06-5)
• EPA Substance Registry System: METHYL THIAZOLIDINE-2-CARBOXYLATE HYDROCHLORIDE(50703-06-5)

Safety Data

• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 50703-06-5(Hazardous Substances Data)

Usage

General Description

Methyl thiazolidine-2-carboxylate hydrochloride is a chemical compound commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is a salt derivative of thiazolidine-2-carboxylic acid, containing a methyl group and a chloride ion. METHYL THIAZOLIDINE-2-CARBOXYLATE HYDROCHLORIDE is known for its ability to act as a chelating agent and is often used in metal-binding reactions. Additionally, it has been studied for its potential antioxidant and anti-inflammatory properties, making it a versatile compound with various potential applications in the fields of medicine and agriculture.

InChI:InChI=1/C5H9NO2S.ClH/c1-8-5(7)4-2-9-3-6-4;/h4,6H,2-3H2,1H3;1H

Upstream product

• 67-56-1 methanol 
• 34592-47-7 L-thioproline 
• 444-27-9 (RS)-4-thiazolidinecarboxylic acid 

Downstream Products

• 270258-77-0 N-methyl-1,3-thiazolidine-4-carboxamide 
• 1103879-74-8 N,N-dimethyl-1,3-thiazolidine-4-carboxamide 

Relevant articles and documents

Transnitrosation of alicyclic N-nitrosamines containing a sulfur atom

Aromatic and aliphatic nitrosamines are known to transfer a nitrosonium ion to another amine. The transnitrosation of alicyclic N-nitroso compounds generates S-nitrosothiols, which are potential nitric oxide donors in vivo. In this study, certain alicyclic N-nitroso compounds based on non-mutagenic N-nitrosoproline or N-nitrosothioproline were synthesised, and the formation of S-nitrosoglutathione (GSNO) was quantified under acidic conditions. We then investigated the effect of a sulfur atom as the substituent and as a ring component on the GSNO formation. In the presence of thiourea under acidic conditions, GSNO was formed from N-nitrosoproline and glutathione, and an N-nitroso compound containing a sulfur atom and glutathione produced GSNO without thiourea. The quantity of GSNO derived from the reaction of the N-nitrosamines containing a sulfur atom and glutathione was higher than that from the N-nitrosoproline and glutathione plus thiourea. Among the analogues that contained a sulfur atom either in the ring or as a substituent, the thiazolidines produced a slightly higher quantity of GSNO than the analogue with a thioamide group. A compound containing sulfur atoms both in the ring and as a substituent exhibited the highest activity for GSNO formation among the alicyclic N-nitrosamines tested. The results indicate that the intramolecular sulfur atom plays an important role in the transnitrosation via alicyclic N-nitroso compounds to form GSNO.

[4R]-3-(Omega-AROYLPROPIONYL)-4-THIAZOLIDINECARBOXYLIC ACIDS AND ESTERS

This disclosure describes novel 4R!-3-(ω-aroylpropionyl)-4-thiazolidinecarboxylic acids and esters and the cationic salts thereof which are useful as hypotensive agents in mammals.