5072-26-4 Usage
Uses
1. Used in Pharmaceutical Research:
DL-Buthionine-[S,R]-SULFOXIMINE is used as a potent and specific inhibitor of alpha-glutamyl cysteine synthetase for studying the role of glutathione in various biological processes and its involvement in diseases.
2. Used in Cancer Research:
DL-Buthionine-[S,R]-SULFOXIMINE is used as a biological tool for depletion of glutathione to examine the apoptotic effects of estrogen on antihormone-resistant human breast cancer cells, enhancing the sensitivity of cancer cells to chemotherapy.
3. Used in Embryonic Development Studies:
DL-Buthionine-[S,R]-SULFOXIMINE is used to investigate the effect of BSO on the development of bovine embryos, providing insights into the role of glutathione in early embryonic development.
4. Used in Toxicology Studies:
DL-Buthionine-[S,R]-SULFOXIMINE is used to inhibit glutathione in several studies, allowing researchers to evaluate the hepatotoxicity and nephrotoxicity of natural food colorants in the absence of glutathione.
5. Used in Oocyte Maturation Research:
DL-Buthionine-[S,R]-SULFOXIMINE is used to investigate the effect of glutathione synthesis on oocyte maturation, contributing to a better understanding of the role of glutathione in reproductive biology.
6. Used in Parasitology:
DL-Buthionine-[S,R]-SULFOXIMINE is used to increase the sensitivity of Trypanosoma cruzi, the parasite responsible for Chagas disease, to antiparasitic drugs such as nifurtimox or benznidazole, potentially improving treatment outcomes for patients.
Biochem/physiol Actions
DL-Buthionine-sulfoximine inhibits the biosynthesis of Glutathione (GSH) in liver and other peripheral organs. It does not have any effect on GSH in the CNS. It augments the antiproliferative action of reactive oxygen species (e.g., hydrogen peroxide), and agents that indirectly cause accumulation of reactive oxygen species (e.g., 2-methoxyestradiol, which increases intracellular superoxide anion).
Check Digit Verification of cas no
The CAS Registry Mumber 5072-26-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,0,7 and 2 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 5072-26:
(6*5)+(5*0)+(4*7)+(3*2)+(2*2)+(1*6)=74
74 % 10 = 4
So 5072-26-4 is a valid CAS Registry Number.
InChI:InChI=1/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)/t7-,14?/m1/s1
5072-26-4Relevant academic research and scientific papers
Methionine and buthionine sulfoximines: Syntheses under mild and safe imidation/oxidation conditions
Buglioni, Laura,Bizet, Vincent,Bolm, Carsten
supporting information, p. 2209 - 2213 (2014/07/21)
Methionine and buthionine sulfoximines (MSO and BSO) are non-natural amino acids known to inhibit the biosynthesis of glutathione (GSH). The current syntheses of these biologically active molecules involve harsh reaction conditions and the use of hazardou
