50724-26-0

Upstream product

• 97-53-0 4-allylguaiacol 
• 2008-75-5 N-chloroethylpiperidine hydrochloride 
• 110-89-4 piperidine 
• 855241-99-5 4-allyl-1-(2-bromo-ethoxy)-2-methoxy-benzene 

Downstream Products

• 1217194-02-9 1-(2-{4-[3-(2,4-dimethoxyphenyl)-4,5-dihydroisoxazol-5-ylmethyl]-2-methoxyphenoxy}ethyl)piperidine 
• 1217194-09-6 1-{2-[2-methoxy-4-(3-naphthalen-1-yl-4,5-dihydroisoxazol-5-ylmethyl)phenoxy]ethyl}piperidine 

Relevant academic research and scientific papers

Synthesis of novel isoxazolines via 1,3-dipolar cycloaddition and evaluation of anti-stress activity

We have synthesized a series of novel isoxazolines via 1,3-dipolar cycloaddition of in situ generated nitrile oxide from 2,4-dimethoxy benzaldoxime and naphthaldehyde oxime with 4-allyl-2-methoxyphenol derivatives. The synthesized compounds were evaluated for anti-stress activity in acute stress (AS) induced peripheral changes. Adult male Sprague-Dawley rats, subjected to AS, cause a significant increase in gastric ulceration, adrenal gland weight, plasma glucose, corticosterone levels, and creatine kinase activity. Compounds 3d, 3g, 5b, 5c, 5d, and 5g displayed most promising anti-stress effect by reverting these peripheral stress parameters at a dose of 40 mg/kg p.o.