507243-05-2

Upstream product

• 134-20-3 2-carbomethoxyaniline 
• 170118-79-3 (E)-1-chloro-4-ethoxy-1,1-difluoro-but-3-en-2-one 
• 334632-48-3 trans-4-Butoxy-1-chloro-1,1-difluorobut-3-en-2-one 

Relevant academic research and scientific papers

Indium-mediated reduction of β-aminovinyl chloro-difluoromethylated ketones in the presence of heteroaryl aldehydes. A mild entry to novel difluoromethylene enaminone derivatives

The synthesis of new β-aminovinyl chloro-difluoromethylated ketones 1 and 2 is presented. In some of them the activation of the C-Cl bond was achieved, under mild conditions, using indium powder. The corresponding difluoro-enolates were trapped with a ser

Indium-mediated reformatsky-type reaction of β-aminovinyl chlorodifluoromethyl ketones with heteroaryl aldehydes

Indium can efficiently mediate the Reformatsky-type reaction between some β-aminovinyl chlorodifluoromethyl ketones and a series of heteroaryl aldehydes, to afford the corresponding difluoromethylene compounds in good to high yields.