507277-19-2

Upstream product

• 507276-76-8 [1-(4-tert-butoxybenzyl)-3-diazo-2-oxo-propyl]-carbamic acid tert-butyl ester 
• 507276-78-0 3-tert-butoxycarbonylamino-4-(4-tert-butoxy-phenyl)-butyric acid methyl ester 
• 565430-84-4 [1-(4-tert-butoxybenzyl)-3-oxo-propyl]-carbamic acid tert-butyl ester 
• 47375-34-8 Boc-Tyr(t-Bu)-OH 
• 479495-63-1 2-benzyl-3-hydroxy-pent-4-enethioic S-benzyl ester 
• 507276-79-1 [1-(4-tert-butoxy-benzyl)-3-hydroxy-pent-4-enyl]-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Unpredictable stereochemical preferences for mu opioid receptor activity in an exhaustively stereodiversified library of 1,4-enediols.

Using olefin cross-metathesis, we synthesized a novel stereodiversified library of compounds 3 containing a trans-1,4-enediol. Screening this library for mu opioid receptor (MOR) affinity identified multiple high-affinity ligands and revealed that the ste