50735-29-0

Upstream product

• 23565-63-1 1-(4-bromophenyl)-3-phenylpropynone 
• 95-54-5 1,2-diamino-benzene 

Relevant academic research and scientific papers

A sustainable water-tolerant catalyst with enhanced Lewis acidity: Dual activation of Cp2TiCl2 via ligand and solvent

A new strategy was developed to enhance the activity of titanocene dichloride for the synthesis of 2,4-disubstituted-3H-benzo[b]-[1,4]diazepine derivatives by using Cp2TiCl2 as a pre-catalyst. The titanocene was activated in situ in the catalytic system via the coordination with m-phthalic acid and alcohol solvent accompanied with the secession of a cyclopentadienyl ring, leading to the formation of an activated species, [CpTi(OEt)2(η1-C8H5O4)]. In particular, the novel developed half-titanocene catalyst exhibited more superior stability than representative half-titanocene complex, indicated by not only water compatibility for the employment of 30 % aqueous ethanol solution but also the recyclability that the products could be generated without apparent yield decrease after 5 runs. In general, we present a paradigm for sustainable molecular catalysis of titanocene.

Method for preparing benzodiazepine compound through efficient catalysis of pyridine palladium

The invention discloses a method for preparing a benzodiazepine compound through efficient catalysis of pyridine palladium. According to the method, an iodobenzene compound, an aryl alkyne compound, an o-phenylene diamine compound and carbon monoxide are

Recyclable gallium(III) triflate-catalyzed [4+3] cycloaddition for synthesis of 2,4-disubstituted-3H-benzo[b][1,4]diazepines

Simple and efficient Ga(OTf)3-catalyzed [4+3] cycloaddition of 1,3-diarylpropynones and o-phenylenediamines is developed for the preparation of 2,4-disubstituted-3H-benzo[b][1,4]diazepines. The reaction has advantages of using a green solvent, generating a minimal amount of waste, and easy catalyst recycle.