50741-47-4

Usage

Uses

Used in Pharmaceutical Industry:
4-Isoquinolinecarboxylic acid, ethyl ester is used as a reagent or intermediate for the synthesis of various pharmaceutical compounds, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
This ester derivative is also utilized as a reagent or intermediate in the production of agrochemicals, playing a role in the creation of pesticides and other agricultural products to enhance crop protection and yield.
Used in Dye and Pigment Manufacturing:
4-Isoquinolinecarboxylic acid, ethyl ester serves as a building block in the manufacture of dyes and pigments, which are essential for coloring textiles, plastics, and various other materials.
Used in Specialty Chemicals Production:
It is employed in the production of specialty chemicals, which have unique applications in industries such as coatings, inks, and cosmetics, due to their specific properties and characteristics.
It is important to handle 4-Isoquinolinecarboxylic acid, ethyl ester with care, as it may be harmful if swallowed or inhaled, and it can cause irritation to the skin and eyes upon contact.

InChI:InChI=1/C12H11NO2/c1-2-15-12(14)11-8-13-7-9-5-3-4-6-10(9)11/h3-8H,2H2,1H3

Upstream product

• 7159-36-6 4-isoquinolinecarboxylic acid 
• 64-17-5 ethanol 
• 1532-97-4 4-bromoisoquinoline 
• 201230-82-2 carbon monoxide 

Relevant academic research and scientific papers

Tandem Tetrahydroisoquinoline-4-carboxylic Acid/β-Alanine as a New Construct Able To Induce a Flexible Turn

Tetrahydroisoquinoline-4-carboxylic acid, a constrained β2-amino acid named β-TIC, was synthesised for the first time in enantiopure form. The biocatalytic route applied herein represents one of the few successful examples of enzymatic resolution of β2-amino acids. Model tetrapeptides, namely, Fmoc-l-Ala-β-TIC-β-Ala-l-Val-OBn (Fmoc=fluorenylmethyloxycarbonyl, Bn=benzyl), containing both isomers of β-TIC, were prepared. Both computational and NMR spectroscopy studies were performed. A reverse-turn conformation was observed in the case of (R)-β-TIC enantiomer that was obtained in 99 % enantiomeric excess by enzymatic resolution. The β-TIC/β-Ala construct represents the first example of a flexible turn mimetic containing a cyclic and an acyclic β-amino acid. Furthermore, the presence of an aromatic ring of β-TIC could facilitate non-covalent interactions to increase the potential of this scaffold for the preparation of protein–protein interaction modulators.

Decahydro-isoquinolines

The invention provides compounds of formula (I), wherein A, B and R are as defined in the description, and the preparation thereof. The compounds of formula (I) are useful as somatostatin receptor antagonists.

PALLADIUM CATALYSED SYNTHESIS OF N AND S HETEROCYCLIC ESTERS

Palladium catalysed alkoxycarbonylation of heterocyclic halides affords a simple and versatile synthesis of both N and S heterocyclic esters where a range of catalysts have been studied and a method to employ inexpensive inorganic bases has been found.