50742-63-7Relevant academic research and scientific papers
DOPAMINE D2 RECEPTOR LIGANDS
-
Page/Page column 239, (2016/07/05)
The present invention relates to novel dopamine D2 receptor ligands. The invention further relates to functionally-biased dopamine D2 receptor ligands and the use of these compounds for treating or preventing central nervous system and systemic disorders associated with dysregulation of dopaminergic activity. The present invention relates to novel compounds that modulate dopamine D2 receptors. In particular, compounds of the present invention show functional selectivity at the dopamine D2 receptors and exhibit selectivity downstream of the D2 receptors, on the 0- arrestin pathway and/or on the cAMP pathway.
Gas Phase Generation and Reactions of o-Dialkylaminobenyzl and o-Dialkylaminophenoxyl Radicals
Cadogan, J. I. G.,Hickson, Clare L.,Husband, James B.,McNab, Hamish
, p. 1891 - 1896 (2007/10/02)
Generation of the title radicals was effected by flash vacuum pyrolysis of benzyl phenyl ethers, and O-allyl ethers, respectively.The major products are formed by a multi-step sequence involving (i) intramolecular hydrogen transfer from the alkylamino group to the initial radical cemtre, (ii) rearrangement of the resulting aminoalkyl radical, (iii) expulsion of the nitrogen residue to give a bezyl radical which leads to products.
Base Catalysed Rearrangements Involving Ylide Intermediates. Part 12. The Preparation and Reactions of 2-Oxidoanilinium Ylides
Ollis, W. David,Sutherland, Ian O.,Thebtaranonth, Yodhathai
, p. 1981 - 1993 (2007/10/02)
2-Oxidoanilinium ylides (22) may be prepared from the corresponding quarternary salts (21) by reaction with aqueous sodium hydroxide.The ylides (22) rearrange on heating to give the products (23) of rearrangements which, on the basis of mixing exper
