507462-51-3

Usage

Uses

Used in Medicinal and Pharmaceutical Chemistry:
5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-amine is used as a building block for the synthesis of bioactive molecules, contributing to the development of new drugs and therapeutic agents. Its pyrrolopyridine structure and bromine atom provide a versatile platform for chemical modifications, enabling the creation of molecules with specific biological activities and properties.
Used in Organic Synthesis:
In the field of organic synthesis, 5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-amine is used as a key intermediate for the development of novel materials and chemical compounds. Its unique structure allows for further derivatization, offering opportunities to explore new chemical reactions and synthesize a wide range of molecules with diverse applications.
Used in the Development of Novel Materials:
5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-amine is utilized in the research and development of new materials, thanks to its potential for modification and the introduction of various functional groups. The bromo substituent on the pyrrolo[2,3-b]pyridine scaffold can be replaced or modified, leading to the creation of materials with tailored properties for specific applications in various industries.

InChI:InChI=1/C7H6BrN3/c8-4-1-5-6(9)3-11-7(5)10-2-4/h1-3H,9H2,(H,10,11)

Upstream product

• 507462-26-2 5-bromo-3-nitro-1H-pyrrolo[2,3-b]pyridine 
• 183208-35-7 5-bromo-1H-pyrrolo[2,3-b]pyridine 

Downstream Products

• 1449319-61-2 1-benzyl-1H-pyrazol-4-carboxylic acid [5-(4-formylphenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide 
• 1449319-59-8 1-benzyl-1H-pyrazol-4-carboxylic acid [5-(4-piperidin-1-ylmethylphenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide 
• 1449319-63-4 1-benzyl-1H-pyrazol-4-carboxylic acid [5-(4-{[(2-methoxyethyl)methylamino]methyl}phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide 
• 1449319-69-0 1-benzyl-1H-pyrazol-4-carboxylic acid {5-[4-(4-fluoropiperidin-1-ylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}amide 
• 1449319-84-9 1-benzyl-1H-pyrazol-4-carboxylic acid [5-bromo-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide 
• 1449319-87-2 1-benzyl-1H-pyrazol-4-carboxylic acid [5-(3-formylphenyl)-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide 
• 1449319-89-4 1-benzyl-1H-pyrazol-4-carboxylic acid [5-(3-dimethylaminomethylphenyl)-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide 
• 1449319-82-7 1-benzyl-1H-pyrazol-4-carboxylic acid [5-(3-dimethylaminomethylphenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide 
• 1449319-96-3 1-benzyl-1H-pyrazol-4-carboxylic acid {5-[3-(3,3-difluoropiperidin-1-ylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}amide 
• 1449319-98-5 1-benzyl-1H-pyrazol-4-carboxylic acid [5-[3-(3,3-difluoropiperidin-1-ylmethyl)phenyl]-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide 
• 1449320-04-0 1-benzyl-1H-pyrazol-4-carboxylic acid [5-(5-pyrrolidin-1-ylmethylthiophen-2-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide 
• 1449320-08-4 1-benzyl-1H-pyrazol-4-carboxylic acid [5-(5-pyrrolidin-1-ylmethylthiophen-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide 
• 1449320-11-9 1-benzyl-1H-pyrazol-4-carboxylic acid {5-[5-(3,3-difluoroazetidin-1-ylmethyl)thiophen-3-yl]-1H-pyrrolo[2,3-b]pyridin-3-yl}amide 
• 1449320-32-4 1-benzyl-1H-pyrazol-4-carboxylic acid [5-(3-hydroxyphenyl)-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide 

Relevant academic research and scientific papers

Tianqitinib, as well as preparation method and application thereof

The invention provides tianqitinib, as well as a preparation method and application thereof, and provides an amide substituted azaindole compound or pharmaceutically acceptable salt thereof, or solvate or prodrug thereof. The compound has a structure as shown in a formula I. The compound can be used for remarkably inhibiting the enzyme activity of TRK at the molecular level, and has remarkable inhibiting effect on phosphorylation/activation of TRK at the cell level. Furthermore, the compound can be used for remarkably inhibiting growth of nude mice xenograft of human tumor cell lines, and hasa wide market application prospect.

Azaindole compound and preparation method and use thereof

The invention provides a compound shown in a formula I, or a pharmaceutically-acceptable salt, or prodrug or hydrate or solvate thereof. The invention further provides a preparation method and use ofthe compound. It is proved through experiments that the compound has a potential as a TPK inhibitor, has a significant inhibitory effect on tumor cells, particularly colon cancer cells, and has a verygood application prospect in the preparation of drugs for treating cancers.

PROTEIN KINASE INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH

The invention relates to MKK4 (mitogen-activated protein kinase 4) and their use in promoting liver regeneration or reducing or preventing hepatocyte death. The MKK4 inhibitors selectively inhibit protein kinase MKK4 over protein kinases JNK and MKK7.

1H-PYRROLO[2,3-B] PYRIDINE DERIVATIVES AND THEIR USE AS KINASE INHIBITORS

The inventions relates to compounds of (I) and therapeutic uses thereof: (I) The terms Z, Y, and R1 are as defined in the claims.

1H-PYRROLO[2,3-B] PYRIDINE DERIVATIVES AND THEIR USE AS KINASE INHIBITORS

The inventions relates to compounds of (I) and therapeutic uses thereof : (I) The terms Z, Y, and R1 are as defined in the claims.