507462-26-2

Usage

Uses

Used in Medicinal Chemistry:
1H-Pyrrolo[2,3-b]pyridine, 5-bromo-3-nitrois used as a building block for the synthesis of various biologically active molecules. Its unique chemical structure and reactivity contribute to the development of new pharmaceutical compounds with potential therapeutic applications.
Used in Pharmaceutical Research and Development:
In the pharmaceutical industry, 1H-Pyrrolo[2,3-b]pyridine, 5-bromo-3-nitroserves as a key intermediate in the research and development of new drugs. Its versatile chemical properties allow for the creation of novel drug candidates with improved efficacy and selectivity.
Used in Agrochemical Research and Development:
1H-Pyrrolo[2,3-b]pyridine, 5-bromo-3-nitrois also utilized in the agrochemical sector for the development of new pesticides and herbicides. Its unique chemical properties enable the design of innovative agrochemicals with enhanced performance and selectivity.
Used in Dyes and Pigments Production:
Due to its unique chemical structure and reactivity, 1H-Pyrrolo[2,3-b]pyridine, 5-bromo-3-nitrohas potential applications in the production of dyes and pigments. Its ability to form stable chromophores makes it a promising candidate for the development of new colorants with improved properties and performance.

Upstream product

• 905966-34-9 5-bromo-3-(2-(trimethylsilyl)ethynyl)pyridine-2-amine 
• 381233-96-1 2-amino-3-iodo-5-bromopyridine 
• 183208-35-7 5-bromo-1H-pyrrolo[2,3-b]pyridine 

Downstream Products

• 1449318-35-7 1-benzyl-1H-pyrazol-4-carboxylic acid (5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)amide 
• 1449319-61-2 1-benzyl-1H-pyrazol-4-carboxylic acid [5-(4-formylphenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide 
• 1449319-59-8 1-benzyl-1H-pyrazol-4-carboxylic acid [5-(4-piperidin-1-ylmethylphenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide 
• 1449319-63-4 1-benzyl-1H-pyrazol-4-carboxylic acid [5-(4-{[(2-methoxyethyl)methylamino]methyl}phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide 
• 1449319-69-0 1-benzyl-1H-pyrazol-4-carboxylic acid {5-[4-(4-fluoropiperidin-1-ylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}amide 
• 1449319-84-9 1-benzyl-1H-pyrazol-4-carboxylic acid [5-bromo-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide 
• 1449319-87-2 1-benzyl-1H-pyrazol-4-carboxylic acid [5-(3-formylphenyl)-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide 
• 1449319-89-4 1-benzyl-1H-pyrazol-4-carboxylic acid [5-(3-dimethylaminomethylphenyl)-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide 
• 1449319-82-7 1-benzyl-1H-pyrazol-4-carboxylic acid [5-(3-dimethylaminomethylphenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide 
• 1449319-96-3 1-benzyl-1H-pyrazol-4-carboxylic acid {5-[3-(3,3-difluoropiperidin-1-ylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}amide 
• 1449319-98-5 1-benzyl-1H-pyrazol-4-carboxylic acid [5-[3-(3,3-difluoropiperidin-1-ylmethyl)phenyl]-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide 
• 1449320-04-0 1-benzyl-1H-pyrazol-4-carboxylic acid [5-(5-pyrrolidin-1-ylmethylthiophen-2-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide 
• 1449320-08-4 1-benzyl-1H-pyrazol-4-carboxylic acid [5-(5-pyrrolidin-1-ylmethylthiophen-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide 
• 1449320-11-9 1-benzyl-1H-pyrazol-4-carboxylic acid {5-[5-(3,3-difluoroazetidin-1-ylmethyl)thiophen-3-yl]-1H-pyrrolo[2,3-b]pyridin-3-yl}amide 

Relevant academic research and scientific papers

Synthesis and Structure-Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3- b]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity

There are currently no approved drugs for the treatment of emerging viral infections, such as dengue and Ebola. Adaptor-associated kinase 1 (AAK1) is a cellular serine-threonine protein kinase that functions as a key regulator of the clathrin-associated host adaptor proteins and regulates the intracellular trafficking of multiple unrelated RNA viruses. Moreover, AAK1 is overexpressed specifically in dengue virus-infected but not bystander cells. Because AAK1 is a promising antiviral drug target, we have embarked on an optimization campaign of a previously identified 7-azaindole analogue, yielding novel pyrrolo[2,3-b]pyridines with high AAK1 affinity. The optimized compounds demonstrate improved activity against dengue virus both in vitro and in human primary dendritic cells and the unrelated Ebola virus. These findings demonstrate that targeting cellular AAK1 may represent a promising broad-spectrum antiviral strategy.

Tianqitinib, as well as preparation method and application thereof

The invention provides tianqitinib, as well as a preparation method and application thereof, and provides an amide substituted azaindole compound or pharmaceutically acceptable salt thereof, or solvate or prodrug thereof. The compound has a structure as shown in a formula I. The compound can be used for remarkably inhibiting the enzyme activity of TRK at the molecular level, and has remarkable inhibiting effect on phosphorylation/activation of TRK at the cell level. Furthermore, the compound can be used for remarkably inhibiting growth of nude mice xenograft of human tumor cell lines, and hasa wide market application prospect.

Azaindole compound and preparation method and use thereof

The invention provides a compound shown in a formula I, or a pharmaceutically-acceptable salt, or prodrug or hydrate or solvate thereof. The invention further provides a preparation method and use ofthe compound. It is proved through experiments that the compound has a potential as a TPK inhibitor, has a significant inhibitory effect on tumor cells, particularly colon cancer cells, and has a verygood application prospect in the preparation of drugs for treating cancers.

PROTEIN KINASE INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH

The invention relates to MKK4 (mitogen-activated protein kinase 4) and their use in promoting liver regeneration or reducing or preventing hepatocyte death. The MKK4 inhibitors selectively inhibit protein kinase MKK4 over protein kinases JNK and MKK7.

1H-PYRROLO[2,3-B] PYRIDINE DERIVATIVES AND THEIR USE AS KINASE INHIBITORS

The inventions relates to compounds of (I) and therapeutic uses thereof: (I) The terms Z, Y, and R1 are as defined in the claims.

1H-PYRROLO[2,3-B] PYRIDINE DERIVATIVES AND THEIR USE AS KINASE INHIBITORS

The inventions relates to compounds of (I) and therapeutic uses thereof : (I) The terms Z, Y, and R1 are as defined in the claims.