50765-12-3Relevant academic research and scientific papers
PHENANTHRENE AMPK ACTIVATOR COMPOUNDS, COMPOSITIONS, METHODS AND USES THEREOF
-
, (2020/11/30)
The present invention relates to a compound having general formula I for use in the activation of AMPK. A composition comprising said compound for use in the activation of AMPK is also provided.
DIRECT AMPK ACTIVATOR COMPOUNDS
-
, (2019/12/25)
The present invention relates to a compound having general formula I for use in the activation of AMPK. A composition comprising said compound for use in the activation of AMPK is also provided. Said compounds are 9,10 dihydrophenanthrenes, in particular selected from the group consisting of: (i) Lusianthridin i.e. 7- Methoxy-9,10-dihydrophenanthrene-2,5-diol, (ii) 7-Methoxy-9,10- dihydrophenanthrene-2,3,5-triol, (iii) 9,10-dihydrophenanthrene-2,5- diol, (iv) 9,10-Dihydrophenanthrene-2,4,7-triol (v) 9,10-Dihydro-7- methoxy-3,5-phenanthrenediol, and the activation of AMPK improves the condition, disorder, or disease related to cardiometabolic health, obesity, type 2 diabetes, non-alcoholic fatty liver disease, cardiovascular disease, and cancer.
Synthesis of Functionalized Alkylidene Indanes and Indanones through Tandem Phosphine-Palladium Catalysis
Fan, Yi Chiao,Kwon, Ohyun
supporting information, p. 2058 - 2061 (2015/05/20)
Densely functionalized alkylidene indanes and indanones can be prepared efficiently in one pot, in high yields with good stereoselectivities (in some cases exclusively the Z-isomer), through a route involving phosphine-catalyzed Michael addition followed
