50768-25-7

Upstream product

• 91962-71-9 rac-1-furan-2-yl-1-phenyl-ethanol 
• 20423-30-7 (4,5-dimethylfuran-2-yl)methanol 
• 98-86-2 acetophenone 

Relevant academic research and scientific papers

Manganese=Catalyzed Achmatowicz Rearrangement Using Green Oxidant H2O2

Oxidation reactions have been extensively studied in the context of the transformations of biomass=derived furans. However, in contrast to the vast literature on utilizing the stoichiometric oxidants, such as m=CPBA and NBS, catalytic methods for the oxidative furan=recyclizations remain scarcely investigated. Given this, we report a means of manganese=catalyzed oxidations of furan with low loading, achieving the Achmatowicz rearrangement in the presence of hydrogen peroxide as an environmentally benign oxidant under mild conditions with wide functional group compatibility.

Selective Functionalization of Achmatowicz Rearrangement Products by Reactions with Potassium Organotrifluoroborates under Transition-Metal-Free Conditions

The repertoire of synthetic transformations of the products of the Achmatowicz rearrangement has been expanded by exploring their reactivity with potassium organotrifluoroborates in the absence of transition metals. Depending on the reaction conditions and the substitution pattern of the starting material, the reaction may lead to the stereoselective synthesis of dihydropyranones (2,6-trans), tetrahydropyranones (2,3-cis-2,6-cis) or functionalized 1,4-dicarbonyl compounds. The method has also been adapted for the one-pot synthesis of functionalized pyrroles.

Oxidation of furans. 2. Synthesis and biological properties of 6 hydroxy 2H pyran 3(6H) ones and derivatives

The anticoccidial and in vitro antimicrobial properties of a series of 6 hydroxy 2H pyran 3(6H) ones VI and theirderivatives were investigated. Compounds VI were readily prepared by the peracid oxidation of the appropriate 2 furanmethanols. Activity was m