5077-96-3

Usage

InChI:InChI=1/C17H32O4/c1-4-7-8-9-10-11-12-13-14-15(16(18)20-5-2)17(19)21-6-3/h15H,4-14H2,1-3H3

Upstream product

• 106-33-2 ethyl laurate 
• 105-58-8 Diethyl carbonate 
• 112-29-8 1-bromo dodecane 
• 996-82-7 sodium diethylmalonate 
• 872-05-9 1-Decene 
• 105-53-3 diethyl malonate 
• 7681-38-1 sodium hydrogen sulfate 
• 2050-77-3 Iododecane 
• 95-92-1 oxalic acid diethyl ester 

Downstream Products

• 862164-99-6 2-decyl-2-[4-(diphenyl-phosphinoyl)-benzyl]-malonic acid diethyl ester 
• 148796-74-1 2-Trityloxymethyl-dodecan-1-ol 
• 148796-65-0 C₃₂H₄₁IO 
• 148820-90-0 Heptyl-(2-trityloxymethyl-dodecyl)-phosphinic acid methyl ester 
• 85689-42-5 2-decylpropanediol-1,3-di(benzenesulphonate) 
• 85689-54-9 C₂₉H₄₄O₈S₂ 
• 2874-75-1 2-ethyldodecanoic acid 
• 82751-25-5 2-Methylsulfanyl-dodecanoic acid ethyl ester 
• 63645-62-5 α-Thiophenoxy-laurinsaeure 
• 116991-29-8 2-Decyl-malonic acid bis-(4-nitro-phenyl) ester 
• 862165-00-2 5-decyl-5-[4-(diphenyl-phosphinoyl)-benzyl]-pyrimidine-2,4,6-trione 
• 4372-29-6 2-n-decyl malonic acid 

Relevant academic research and scientific papers

New 1,3-dioxane type ionic liquid crystal compounds having a different counter anion

New pyridinium type thermotropic ionic liquid crystal materials having a 1,3-dioxane ring in their central core: N-substituted-4-(5-alkyl-1,3-dioxan-2-yl)pyridinium halides (6) were synthesized. These compounds exhibited a smectic A phase over a very wide temperature range including room temperature [for example 6-5: G -24 SmA 152 I (°C)]. The size of the counter anion affected the transition temperatures between the isotropic state and the smectic A phase.

NOVEL MESITYLENE-CORED AMPHIPHILES AND USES THEREOF

The present invention relates to a mesitylene-cored amphiphile, a method of preparing the same and a method of extraction, solubilization, stabilization, crystallization or analysis of a membrane protein using the same. When a mesitylene-cored compound according to the present invention is used, membrane proteins can be stored in a stable conformation for a long time in an aqueous solution in comparison with conventional compounds, by which the membrane proteins are usable in both functional and structural analyses thereof. The functional and structural analyses of membrane proteins are one of the fields that are most spotlighted in current biology and chemistry. The present invention can be used to research on a protein structure closely related to new drug development.

Unsymmetrical spiroalkanedithiols having mixed fluorinated and alkyl tailgroups of varying length: Film structure and interfacial properties

A custom-designed series of unsymmetrical spiroalkanedithiols having tailgroups comprised of a terminally fluorinated chain and a hydrocarbon chain of varying lengths were synthesized and used to prepare self-assembled monolayers (SAMs) on gold substrates. The specific structure of the adsorbates was of the form [CH3(CH2)n][CF3(CF2)7(CH2)8]C[CH2SH]2, where n = 7, 9, and 15 (designated as F8H10-C10, F8H10-C12, and F8H10-C18, respectively). The influence of the length of the hydrocarbon chain in the bidentate dithiol on the structure and interfacial properties of the monolayer was explored. A structurally analogous partially fluorinated monodentate alkanethiol and the corresponding normal alkanethiols were used to generate appropriate SAMs as reference systems. Measurements of ellipsometric thickness showed an unexpectedly low film thickness for the SAMs derived from the bidentate adsorbates, possibly due to disruptions in interchain packing caused by the fluorocarbon chains (i.e., phase-incompatible fluorocarbon-hydrocarbon interactions), ultimately giving rise to loosely packed and disordered films. Analysis by X-ray photoelectron spectroscopy (XPS) were also consistent with a model in which the films were loosely packed; additionally, the XPS spectra confirmed the attachment of the sulfur headgroups of the bidentate adsorbates onto the gold substrates. Studies of the SAMs by polarization modulation-infrared reflection-adsorption spectroscopy (PM-IRRAS) suggested that as the length of the hydrocarbon chain in the adsorbates was extended, a more ordered surface was achieved by reducing the tilt of the fluorocarbon segment. The wettability data indicated that the adsorbates with longer alkyl chains were less wettable than those with shorter alkyl chains, likely due to an increase in interchain van der Waals forces in the former.

NOVEL XYLENE-BASED AMPHIPHILIC COMPOUND AND USE THEREOF

The present invention relates to a xylene-based amphiphilic compound, a method for preparing the same, and a method for extracting, solubilizing, stabilizing or crystallizing a membrane protein using the same. By using the xylene-based compound according to the present invention, a membrane protein may be stably stored in an aqueous solution for a long time, and may be applied in functional and structural analyses. The structural and functional analysis of the membrane protein is one of the fields of highest interest in biology and chemistry, and the xylene-based compound according to the present invention can be applied in research on protein structure that is closely related to development of a new drug.

Mesitylene-Cored Glucoside Amphiphiles (MGAs) for Membrane Protein Studies: Importance of Alkyl Chain Density in Detergent Efficacy

Detergents serve as useful tools for membrane protein structural and functional studies. Their amphipathic nature allows detergents to associate with the hydrophobic regions of membrane proteins whilst maintaining the proteins in aqueous solution. However

Novel Xylene-Linked Maltoside Amphiphiles (XMAs) for Membrane Protein Stabilisation

Membrane proteins are key functional players in biological systems. These biomacromolecules contain both hydrophilic and hydrophobic regions and thus amphipathic molecules are necessary to extract membrane proteins from their native lipid environments and

Multiple hydrogen bonded mesomorphic complexes between complementary 1,3,5-triazine and pyrimidine derivatives

A 2,4-diamino-6-phenyl-1,3,5-triazine grafted with two semiperfluorinated chains at the phenyl substituent has been investigated in binary mixtures with complementary orotic acid and barbituric acid derivatives carrying either a lipophilic alkyl or a semiperfluoroalkyl tail. Equimolar mixtures of the triazine with nucleobases form triple hydrogen-bonded heterodimers with an elongated central core. Mesomorphic properties are observed only if the pyrimidinone component provides an additional free NH function not involved in triple H-bonding with the triazine nucleus. In that case, additional H-bond interactions orthogonal to the rod-shaped core of the heterodimers initiate the formation of cyclotrimeric rosette-type associates with circular geometry of the polar core region. Rosettes of heterodimers involving an alkyl substituted nucleobase organize to hexagonal columnar mesophases. Replacing the alkyl tail of the pyrimidine with a semiperfluorinated fragment leads to the formation of a micellar cubic phase. The individual micelles are composed of segmented columns three-dimensionally surrounded by a continuum of the semiperfluorinated segments.

Preparation and application of odorless 1,3-propanedithiol reagents

2-Dodecyl-1,3-propanedithiol (2a) was prepared without a malodorous procedure as an odorless reagent that was usable in place of 1,3-propanedithiol (1) in organic reactions, e.g., in the reduction of azides and protection of carbonyl groups. The 1,3-dithioacetals obtained in the latter reaction were effectively reduced to methylene with Raney nickel and reconverted to the original carbonyl compounds by hydrolysis with N-bromosuccinimide in aqueous 2-butanone. In addition, the anion of 1,3-dithiane prepared from 2a and formaldehyde could be utilized as a synthetic equivalent of an anionic carbonyl carbon.

Recyclable self-assembly-supported catalytic system for orthoalkylation

(Chemical Equation Presented) A new recyclable supported catalyst system for orthoalkylation was devised using a self-assembly consisting of the barbiturate and 2,4,6-triaminopyrimidine H-bonding motifs. At high temperature, the system is completely homog

Barbituric acid derivatives with antimetastatic and antitumor activity

The invention is directed to barbituric acid derivatives having inhibitory activity for matrix maetalloproteases comprised of formula (I): pharmaceutical compositions thereof, processes for preparing the derivatives, and methods for treating diseases associated with elevated or uncontrolled levels of matrix metalloprotease activity, e.g., cancer, specifically tumor progression and tumor metastasis, inflammation, or as a method of contraception.