50781-57-2Relevant academic research and scientific papers
NOVEL SYNTHESIS OF PYRIDOPYRIMIDINES, PYRIDOPYRIMIDINES, AND QUINAZOLINES VIA PALLADIUM-CATALYZED OXIDATIVE COUPLING
Hirota, Kosaku,Kuki, Hideki,Maki, Yoshifumi
, p. 563 - 570 (1994)
Oxidative-coupling of 6-azavinyl(or vinyl)-1,3-dimethyluracil derivatives (1,5, and 7) with electron-deficient olefins in the presence of palladium acetate led to the formation of the corresponding 6-substituted pyridopyrimidines (4), pyrido
Efficient one-pot synthesis of substituted pyrido[2,3-d]pyrimidines from vinamidinium and chloropropeniminium salts
Ayed, Mohamed Adnen Hadj,Gmiza, Thouraya,Khiari, Jamel Eddine,Hassine, Bechir Ben
supporting information; experimental part, p. 1824 - 1831 (2012/04/23)
A novel and efficient one-pot preparation of 6-substituted pyrido-[2,3-d]pyrimidines by cyclocondensation of 6-amino-1,3-dimethyluracil with symmetrical vinamidinium salts under basic conditions has been developed. Regioselectivity was observed with an unsymmetrical chloropropeniminium salt. Copyright Taylor & Francis Group, LLC.
A new synthesis of 6-substituted pyrido [2,3-d]pyrimidines
Kuwada, Takeshi,Harada, Kenichi,Nobuhiro, Junko,Choshi, Tominari,Hibino, Satoshi
, p. 2081 - 2090 (2007/10/03)
The reaction of the β-methylsulfanylacroleins, derived from alkenyl sulfides by the Vilsmeier reaction, with 6-aminouracils or 2,6-diaminouracil, provides a new synthetic route to the 6-substituted pyrido[2,3-d]pyrimidines by two methods, the reaction mec
Synthesis of pyrido[2,3-d]pyrimidines via palladium-catalyzed coupling reaction followed by electrocyclic reaction
Rho, Kee Yoon,Kim, Joong Hyup,Kim, Sung Hoon,Yoon, Cheol Min
, p. 2521 - 2528 (2007/10/03)
Pyrido[2,3-d]pyrimidines (5a-h) were regioselectively synthesized by the reaction of 5-iodo-6-(dimethylaminomethylene)amino-1,3-dimethyluracil(3), which was prepared from the reaction of 6-amino-1,3-dimethyluracil with dimethylformamide dimethyl acetal followed by iodination, with various olefins (4a-h) in the presence of a catalytic amount of Pd(OAc)2, Cul, and K2CO3 in DMF at 100 °C.
