50799-24-1Relevant articles and documents
1-(2-Substituted-chromonyloxy)-2-hydroxy-3-(substituted phenoxy)propanes
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, (2008/06/13)
Definitions: in the following Formulae I, II and IV, R1 represents hydrogen, alkyl of 1 to 4 carbon atoms, or a nontoxic cation, while each of R2, R3, R4, R5, and R6 symbolizes hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, carboxy, carbalkoxy of 1 to 4 carbon atoms, trihalomethyl, halogen, nitro or cyano. Certain 1-(2-substituted-chromon-yloxy)-2-hydroxy-3-(substituted-phenoxy)propanes (Formula I), SPC1 can be synthesized from intermediate bis-(substituted-phenoxy)propanes (Formula II), SPC2 by condensation with diethyl oxalate in the presence of sodium ethoxide followed by cyclization with a mixture of glacial acetic acid and concentrated sulfuric or a mixture of concentrated hydrochloric acid and a lower alcohol containing up to 4 carbon atoms. The bis-(substituted-phenoxy)propane intermediates (Formula II) are prepared by reacting a dihydroxyacetophenone (Formula III), SPC3 with a (substituted-phenyl)glycidyl ether (Formula IV), SPC4 in an organic solvent in the presence of a catalyst. The 1-(2-substituted-chromon-yloxy)-2-hydroxy-3-(substituted-phenoxy)propanes (Formula I) are useful in the treatment of allergic conditions in mammals. The bis-(substituted-phenoxy)propanes (Formula II) are useful as intermediates in the synthesis of the latter compounds. Methods of preparing compounds having Formulae I and II are described. Methods of treating allergic conditions in mammals utilizing compounds of Formula I are also disclosed.