508-88-3 Usage
Uses
Used in Pharmaceutical Industry:
(17α)-3α,14-Dihydroxy-5β-card-20(22)-enolide is used as a therapeutic agent for the treatment of congestive heart failure and arrhythmias. It functions by inhibiting the sodium-potassium pump in the cell membrane, which results in increased intracellular calcium levels, thereby enhancing cardiac contractility and reducing heart rate.
Used in Molecular Biology:
In the field of molecular biology, (17α)-3α,14-Dihydroxy-5β-card-20(22)-enolide serves as a valuable tool for the detection and localization of nucleic acids. Its unique properties allow for specific interactions with biological molecules, making it useful in various diagnostic and research applications.
Used in Anti-inflammatory and Anti-cancer Research:
(17α)-3α,14-Dihydroxy-5β-card-20(22)-enolide is also being explored for its potential anti-inflammatory and anti-cancer properties. Its ability to modulate cellular processes suggests that it may have applications in treating inflammatory conditions and inhibiting the growth of cancer cells.
However, due to the risk of toxicity and overdose associated with (17α)-3α,14-Dihydroxy-5β-card-20(22)-enolide, it is crucial that its use is carefully managed and monitored under medical supervision to ensure patient safety and effectiveness.
Check Digit Verification of cas no
The CAS Registry Mumber 508-88-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,0 and 8 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 508-88:
(5*5)+(4*0)+(3*8)+(2*8)+(1*8)=73
73 % 10 = 3
So 508-88-3 is a valid CAS Registry Number.
InChI:InChI=1/C23H34O4/c1-21-8-5-16(24)12-15(21)3-4-19-18(21)6-9-22(2)17(7-10-23(19,22)26)14-11-20(25)27-13-14/h11,15-19,24,26H,3-10,12-13H2,1-2H3/t15-,16+,17+,18+,19-,21+,22-,23+/m1/s1
508-88-3Relevant academic research and scientific papers
BIOTRANSFORMATION OF DIGITOXIGENIN BY CELL SUSPENSION CULTURES OF STROPHANTHUS DIVARICATUS
Kawaguchi, Kiichiro,Hirotani, Masao,Furuya, Tsutomu
, p. 1503 - 1506 (2007/10/02)
Eight compounds, including a new compound (3-epi-17βH-gitoxigenin) were isolated as biotransformation products of digitoxigenin by cell suspension cultures of Strophanthus divaricatus.At the same time, three products were identified by TLC and HPLC. 16β-Hydroxylation and isomerization of the 17β-butenolide ring of digitoxigenin molecule were demonstrated using this cell suspension culture. Key Word Index - Strophanthus divaricatus; Apocynaceae; biotransformation; 16β-hydroxylation; isomerization of 17β-butenolide ring; cardenolides; digitoxigenin; 17βH-gitoxigenin; 3-epi-17βH-gitoxigenin.
BIOTRANSFORMATION OF DIGITOXIGENIN BY GINSENG HAIRY ROOT CULTURES
Kawaguchi, Kiichiro,Hirotani, Masao,Yoshikawa, Takafumi,Furuya, Tsutomu
, p. 837 - 843 (2007/10/02)
Five new compounds (three esters and two glycosides) and seven previously reported compounds were isolated as biotransformation products of digitoxigenin by ginseng hairy root cultures.The new esters and glycosides were elucidated as digitoxigenin stearate, digitoxigenin palmitate, digitoxigenin myristate, 3-epidigitoxigenin β-D-gentiobioside and digitoxigenin β-D-sophoroside using 1H and 13C NMR and FAB mass spectral data.Biotransformations involving esterification (of stearic acid, palmitic acid, myristic acid and lauric acid) and glycosylation (of gentiobiose and sophorose) of digitoxigenin have been demonstrated for the first time in the plant cell and tissue cultures.The hairy roots showed high glycosylation ability to the digitoxigenin molecule.
