50800-82-3

Usage

Derivative of pyrazole

yes

Also known as

Cl-4-phenylpyrazole

Potential applications

medicinal chemistry

Investigated as

antitumor agent, selective inhibitor of aromatase enzyme

Role

modulation of various biological processes

Upstream product

• 20725-25-1 1,3-bis(4-chlorophenyl)prop-2-en-1-one 
• 99-91-2 para-chloroacetophenone 
• 104-88-1 4-chlorobenzaldehyde 
• 19672-59-4 (E)-1,3-di(4-chlorophenyl)-2-propen-1-one 

Downstream Products

• 1381883-56-2 (3,5-bis(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)(6-methylpyridin-3-yl)methanone 
• 1381883-52-8 (3,5-bis(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)(5-bromopyridin-3-yl)methanone 
• 1381883-53-9 (3,5-bis(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)(6-chloropyridin-3-yl)methanone 
• 1381883-55-1 (3,5-bis(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)(2-chloropyridin-3-yl)methanone 
• 1381883-54-0 (3,5-bis(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)(2-chloro-6-methylpyridin-3-yl)methanone 
• 37865-30-8 3,5-bis-(4-chloro-phenyl)-4,5-dihydro-pyrazole-1-carbothioic acid anilide 
• 1235721-92-2 [3-(4-chlorophenyl)-5-(4-chlorophenyl)-4,5-dihydropyrazol-1-yl](pyridine-4-yl)methanone 

Relevant academic research and scientific papers

N1-benzenesulfonyl-2-pyrazoline hybrids in neurological disorders: Syntheses, biological screening and computational studies

A novel series of 1,3,5-trisubstituted-2-pyrazolines (5a-5t) was prepared via Claisen Schmidt condensation, followed by heterocyclization with hydrazine hydrate, substitution of N1 hydrogen of 2-pyrazoline nucleus with 4-chlorobenzenesulfonylchloride, app

Derivatives of 4,5-dihydro (1H) pyrazoles as possible MAO-A inhibitors in depression and anxiety disorders: synthesis, biological evaluation and molecular modeling studies

A series of 1,3,5-trisubstituted-2-pyrazoline derivatives (3a–3t) were synthesized in appreciable yields by substituting N1 position of 2-pyrazoline nucleus with 4-nitrobenzenesulfonylchloride using conventional and microwave assisted synthetic approaches

An expeditious one-pot microwave facilitated versus conventional syntheses: In vivo biological screening and molecular docking studies of some 3,5-disubstituted-4,5-dihydro-(1H)-pyrazole derivatives

A series of 3,5-disubstituted-2-pyrazoline derivatives (2a-2t) were synthesized by reacting different aromatic/heteroaromatic aldehydes and ketones, in a two-step reaction through Claisen Schmidt condensation, followed by cyclization of the resulted chalc

Discovery and Pharmacophore Studies of Novel Pyrazole-Based Anti-Melanoma Agents

Due to the rising incidence and lack of effective treatments, malignant melanoma is the most dangerous form of skin cancer, so that new treatment strategies are urgently needed. Several recent developments indicate that the V600E mutant BRAF (BRAFV60

SOCl2 catalyzed cyclization of chalcones: Synthesis and spectral studies of some bio-potent 1H pyrazoles

Some aryl-aryl 1H pyrazoles have been synthesised by cyclization of aryl chalcones and hydrazine hydrate in the presence of SOCl2. The yields of the pyrazoles are more than 85%. These pyrazoles are characterized by their physical con

Synthesis, biological evaluation and 3D-QSAR studies of novel 4,5-dihydro-1H-pyrazole niacinamide derivatives as BRAF inhibitors

A series of novel 4,5-dihydropyrazole derivatives containing niacinamide moiety as potential V600E mutant BRAF kinase (BRAFV600E) inhibitors were designed and synthesized. Results of the bioassays against BRAF V600E and WM266.4 human