5081-17-4Relevant academic research and scientific papers
A USEFUL METHOD TO INTRODUCE ORTHO AMINO GROUPS IN AROMATIC COMPOUNDS
Narasimhan, Nurani S.,Ammanamanchi, RadhaKrishna
, p. 4733 - 4734 (1983)
Aromatic lithio compounds were reacted with tosyl azide and the resulting triazenes, in situ, were reduced with Ni-Al alloy to give primary aromatic amines.
Development of novel 2-[4-(aminoalkoxy)phenyl]-4(3H)-quinazolinone derivatives as potent and selective histamine H3 receptor inverse agonists
Mizutani, Takashi,Nagase, Tsuyoshi,Ito, Sayaka,Miyamoto, Yasuhisa,Tanaka, Takeshi,Takenaga, Norihiro,Tokita, Shigeru,Sato, Nagaaki
scheme or table, p. 6041 - 6045 (2009/06/30)
Novel 2-[4-(aminoalkoxy)phenyl]-4(3H)-quinazolinone derivatives were identified as potent human H3 receptor inverse agonists. After systematic modification of lead 5a, the potent and selective analog 5r was identified. Elimination of hERG K+ channel and human α1A-adrenoceptor activities is the main focus of the present study.
FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS
-
Page/Page column 464, (2008/12/05)
The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R1, R2, R3, R4, R5, A1, A2, A3, A4, and A5, are as defined herein. The compounds of formula I or II have ALK and/or c-Met inhibitory activity, and may be used to treat proliferative disorders.
