508212-17-7

Upstream product

• 508212-16-6 methyl [3-methoxy-4-(methoxymethoxy)phenyl]acetate 
• 97-53-0 4-allylguaiacol 
• 306-08-1 Homovanillic acid 

Downstream Products

• 350803-06-4 (3-methoxy-4-methoxymethoxy-phenyl)-acetic acid pentafluorophenyl ester 
• 143654-10-8 (3E,10E)-(S)-12-[2-(2-Dimethylamino-ethyl)-4-methoxy-5-methoxymethoxy-phenyl]-2,6,10-trimethyl-2-triethylsilanyloxy-dodeca-3,10-dien-5-one 
• 143654-10-8 (3E,10E)-(R)-12-[2-(2-Dimethylamino-ethyl)-4-methoxy-5-methoxymethoxy-phenyl]-2,6,10-trimethyl-2-triethylsilanyloxy-dodeca-3,10-dien-5-one 
• 143654-09-5 (3E,10E)-(S)-12-[2-(2-Dimethylamino-ethyl)-4-methoxy-5-methoxymethoxy-phenyl]-2,6,10-trimethyl-2-triethylsilanyloxy-dodeca-3,10-dien-5-ol 
• 143654-09-5 (3E,10E)-(R)-12-[2-(2-Dimethylamino-ethyl)-4-methoxy-5-methoxymethoxy-phenyl]-2,6,10-trimethyl-2-triethylsilanyloxy-dodeca-3,10-dien-5-ol 
• 143654-06-2 (E)-(S)-8-(tert-Butyl-dimethyl-silanyloxy)-1-[2-(2-dimethylamino-ethyl)-4-methoxy-5-methoxymethoxy-phenyl]-3,7-dimethyl-oct-1-en-3-ol 
• 143654-06-2 (E)-(R)-8-(tert-Butyl-dimethyl-silanyloxy)-1-[2-(2-dimethylamino-ethyl)-4-methoxy-5-methoxymethoxy-phenyl]-3,7-dimethyl-oct-1-en-3-ol 
• 143654-07-3 (2-{2-[(E)-(S)-8-(tert-Butyl-dimethyl-silanyloxy)-3,7-dimethyl-oct-2-enyl]-5-methoxy-4-methoxymethoxy-phenyl}-ethyl)-dimethyl-amine 
• 143654-07-3 (2-{2-[(Z)-(S)-8-(tert-Butyl-dimethyl-silanyloxy)-3,7-dimethyl-oct-2-enyl]-5-methoxy-4-methoxymethoxy-phenyl}-ethyl)-dimethyl-amine 
• 143654-07-3 (2-{2-[(E)-(R)-8-(tert-Butyl-dimethyl-silanyloxy)-3,7-dimethyl-oct-2-enyl]-5-methoxy-4-methoxymethoxy-phenyl}-ethyl)-dimethyl-amine 
• 143654-07-3 (2-{2-[(Z)-(R)-8-(tert-Butyl-dimethyl-silanyloxy)-3,7-dimethyl-oct-2-enyl]-5-methoxy-4-methoxymethoxy-phenyl}-ethyl)-dimethyl-amine 
• 143654-12-0 (S)-Debromoneoaplaminone 
• 143654-00-6 (R)-debromoneoaplaminone 

Relevant academic research and scientific papers

BENZENE DERIVATIVES,PROCESS FOR PREPARING THE SAME AND USE THEREOF

Novel benzene derivatives represented by the formula (I) : wherein R1, R4 and R6 each independently represents a hydrogen atom, a halogen atom or a hydrocarbon group, R2 represents a hydrocarbon group or a heterocyclic group, R3 represents a hydrocarbon group, NR7'R7 or OR8 (wherein R7' represents a hydrogen atom or a hydrocarbon group, R7 represents a non-aromatic group, or R7' and R7 may form a ring with the adjacent nitrogen atom, and R8 represents a hydrocarbon group or a heterocyclic group), R5 represents a hydrocarbon group or a heterocyclic group (except for a quinolyl group), R5' represents a hydrogen atom, or a hydrocarbon group, or R5 and R5' may form a ring with the adjacent nitrogen atom, and R5" represents a hydrogen atom or a hydrocarbon group, which have vanilloid receptor agonist activity and are useful as a drug such as an analgesic and an agent for preventing and/or treating urinary frequency and/or urinary incontinence.

Vanilloid and isovanilloid analogues as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases

As aminoacyl adenylate surrogates, a series of methionyl and isoleucyl phenolic analogues containing bioisosteric linkers mimicking ribose have been investigated. Inhibition of synthesized compounds to the aminoacylation reaction by the corresponding Escherichia coli methionyl-tRNA and isoleucyl-tRNA synthetases indicated that 18 was found to be a potent inhibitor of isoleucyl-tRNA synthetase. A molecular modeling study demonstrated that in 18, isovanillate and hydroxamate served as proper surrogates for adenine and ribose in isoleucyl adenylate, respectively.

Absolute Stereochemistry of Aplaminone and Neoaplaminone, Cytotoxic Bromodopamines from a Marine Mollusc: Enantioselective Synthesis of Debromoneoaplaminone

The absolute stereochemistry of potent cytotoxic bromodopamines, aplaminone and neoaplaminone has been determined by means of enantioselective synthesis of debromoneoaplaminone, a derivative of aplaminone and neoaplaminone.