50823-87-5

Usage

Uses

Used in Pharmaceutical Industry:
4-Methoxy-3-(trifluoromethyl)benzaldehyde is used as an intermediate in the synthesis of various organic compounds and pharmaceuticals. Its unique structure and properties make it a key component in the development of new drugs, enhancing their efficacy and pharmacological profiles.
Used in Agrochemical Research:
In the agrochemical industry, 4-Methoxy-3-(trifluoromethyl)benzaldehyde is used as a building block for the development of new agrochemicals. The trifluoromethyl group imparts significant chemical and biological properties to the compound, making it a valuable asset in the creation of effective and innovative agricultural products.
Used in Organic Chemistry:
4-Methoxy-3-(trifluoromethyl)benzaldehyde is utilized as a versatile intermediate in organic chemistry for the synthesis of a wide range of compounds. Its unique combination of functional groups allows for diverse synthetic pathways and the creation of complex organic molecules with potential applications in various fields.

InChI:InChI=1/C9H7F3O2/c1-14-8-3-2-6(5-13)4-7(8)9(10,11)12/h2-5H,1H3

Upstream product

• 1514-11-0 4-bromo-1-methoxy-2-(trifluoromethyl)benzene 
• 68-12-2 N,N-dimethyl-formamide 
• 100-97-0 hexamethylenetetramine 
• 395-48-2 1-methoxy-2-(trifluoromethyl)benzene 
• 220227-98-5 4-hydroxy-3-(trifluoromethyl)benzaldehyde 
• 213598-09-5 4-methoxy-3-(trifluoromethyl)benzoic acid 

Downstream Products

• 955038-23-0 4-Methoxy-3-trifluoromethylphenylacetaldehyde 
• 1601462-22-9 (E,E)-1-hydroxy-2,5-bis(3-trifluoromethyl-4-methoxy)styrylbenzene 
• 1601462-23-0 (E,E)-1-methoxy-2,5-bis(3-trifluoromethyl-4-methoxy)styrylbenzene 
• 240400-71-9 N-[4-methoxy-3-(trifluoromethyl)benzyl]formamide 
• 372103-49-6 2-(3-trifluoromethyl-4-methoxyphenyl)-3-methoxy-6-methyl-8-(4-pyridinyl)-4H-chromen-4one 
• 95333-91-8 1-(4-Methoxy-3-trifluoromethyl-benzyl)-1,3-dihydro-imidazole-2-thione 
• 95333-61-2 1-[4-hydroxy-3-(trifluoromethyl)benzyl]imidazole-2-thione 

Relevant academic research and scientific papers

Electricity Driven 1,3-Oxohydroxylation of Donor-Acceptor Cyclopropanes: a Mild and Straightforward Access to β-Hydroxy Ketones

An unprecedented external oxidant-free electrochemical protocol for 1, 3-oxohydroxylation of donor-acceptor cyclopropane is disclosed. The strategy encompasses the activation of the labile π-electron cloud of the aryl ring to cleave the strained Csp3?Csp3 bond of cyclopropane to afford the β-hydroxy ketones via insertion of molecular oxygen. More significantly, based on the detailed mechanistic investigations and cyclic voltammetry experiments, a plausible mechanism is proposed.

Syntheses and biological evaluation of 1,2,3-triazole and 1,3,4-oxadiazole derivatives of imatinib

Three novel series of 1,2,3-triazole and 1,3,4-oxadiazole derivatives of imatinib were prepared and evaluated in vitro for their cytostatic effects against a human chronic myeloid leukemia (K562), acute myeloid leukemia (HL60), and human leukemia stem-like cell line (KG1a). The structure-activity relationship was analyzed by determining the inhibitory rate of each imatinib analog. Benzene and piperazine rings were necessary groups in these compounds for maintaining inhibitory activities against the K562 and HL60 cell lines. Introducing a trifluoromethyl group significantly enhanced the potency of the compounds against these two cell lines. Surprisingly, some compounds showed significant inhibitory activities against KG1a cells without inhibiting common leukemia cell lines (K562 and HL60). These findings suggest that these compounds are able to inhibit leukemia stem-like cells.

Phthalazine derivatives and remedies for erectile dysfunction

The present invention provides a phthalazine compound as a therapeutic agent for erectile dysfunction represented by the following formula, a pharmacologically acceptable salt thereof or a hydrate thereof: wherein R1and R2are the same as or different from each other and represent a halogen atom, a C1 to C4 alkyl group which may be substituted with a halogen atom, a C1 to C4 alkoxy group which may be substituted with a halogen atom or a cyano group; X represents a cyano group, a nitro group, a halogen atom, a hydroxyimino group which may be substituted or a heteroaryl group which may be substituted; Y represents a heteroaryl group, an aryl group which may be substituted, an alkynyl group which may substituted, an alkenyl group, an alkyl group, an optionally substituted saturated or unsaturated 4- to 8-membered amine ring, and the cyclic amine compound is a monocyclic compound, bicyclic compound or a spiro compound; l is an integer of 1 to 3; provided that the case where l is 1 or 2, X is a cyano group, a nitro group or a chlorine atom, R1is a chlorine atom, R2is a methoxy group and Y is a 5- or 6-membered amine ring substituted with a hydroxyl group is excluded.