5083-62-5Relevant academic research and scientific papers
ANTI-OPIOID VACCINES
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Page/Page column 14, (2018/05/24)
The invention provides haptens and methods of preparation thereof, for producing immunoconjugates of oxycodone and hydrocodone suitable for raising antibodies in animals specific for the opioid drugs. Adminislration of the opioid-speeific antibodies to humans having the opioid drugs in a body fluid such as blood serum, binds the opioid drugs to the antibody, making the opioids unavailable for producing a drug effect. Accordingly the antibodies can be used to reverse the effects of a drug overdose of oxycodone and hydrocodone, or to reverse a perceived mental effect of the. drugs, such as euphoria.
N-Demethylation of 6-Keto Morphinans
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, (2012/02/15)
The present invention provides processes for the demethylation of an N-methyl morphinan comprising a ketone functional group. In particular, the invention provides methods for the protection of the ketone functional group such that impurities are not generated during the demethylation of the N-methyl morphinan.
METHODS FOR N-DEMETHYLATION OF MORPHINE AND TROPANE ALKALOIDS
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Page/Page column 3, (2009/01/24)
The present invention provides a method for the N-demethylation of an N-methylated heterocycle, particularly a morphine or tropane alkaloid or derivative thereof. The method comprises reacting the heterocycle with a metal catalyst and a solvent in the presence of an oxidizing agent.
Biotransformations of morphine alkaloids by fungi: N-demethylations, oxidations, and reductions
Chaudhary, Vigi,Leisch, Hannes,Moudra, Alena,Allen, Blake,De Luca, Vincenzo,Cox, D. Phillip,Hudlicky, Tomas
experimental part, p. 1179 - 1193 (2010/04/26)
Morphine alkaloids and some of its derivatives (morphine, codeine, thebaine, oripavine, hydrocodone, and oxycodone) were subjected to fermentations with six fungal strains. The alkaloids were transformed to a variety of products via biological oxidations, reductions, and oxidative demethylations. The strain Cunninghamella echinulata proved to be the most effective for demethylations of all of the above compounds, except for morphine. The time profile of the conversion of 3-[14CH3]thebaine to 3-[ 14CH3]northebaine by C. echinulata cultures was also determined.
14,17-Cyclonorcodeinone dimethylacetal: A New Codeinon Derivative, II
Fleischhacker, W.,Richter, B.,Voellenkle, H.
, p. 399 - 411 (2007/10/02)
In addition to a short communication describing the synthesis of 14,17-cyclonorcodeinone dimethylacetal 1a we wish to present a simple alternative route together with a selection of some reactions depending on the great reactivity of this highly strained small ring system.The structure of 1a is established by X-ray analysis.
7,8 and 7-8 Substituted 4,5α-epoxymorphinan-6-one compounds, and methods of treating pain and drug dependence with them
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, (2008/06/13)
Disclosed are 7,8 and 7-8 substituted 4,5α-epoxymorphinan-6-one compounds characterized by the structural formula: STR1 In the foregoing formula R1 may be H or methyl, R2 is cyclopropylmethyl, cyclobutylmethyl, allyl or tetrahydrofurfuryl, R3 is H, β-methyl, β-ethyl or α-ethyl and R4 is H or α-methyl. Particular compounds corresponding to the foregoing description are useful as mixed analgesics/narcotic antagonists whereas others have been found to be pure narcotic antagonists.
