50835-77-3

Usage

Synthesis Reference(s)

Synthetic Communications, 2, p. 227, 1972 DOI: 10.1080/00397917208081772

Upstream product

• 1490-25-1 succinic acid monomethylester chloride 
• 75-44-5 phosgene 
• 4138-35-6 methyl 3-aminopropanoate 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 3196-73-4 methyl 3-aminopropanoate hydrochloride 

Downstream Products

• 35052-49-4 N-(N-benzyloxycarbonyl-β-alanyl)-β-alanine methyl ester 
• 99841-39-1 N-phenylcarbamoyl-β-alanine methyl ester 
• 54755-77-0 N-benzyloxycarbonyl-3-aminopropionic acid methyl ester 
• 100796-05-2 3-(2,5-dioxo-4-phenyl-imidazolidin-1-yl)-propionic acid methyl ester 
• 1056623-63-2 C₁₆H₂₁ClN₂O₄ 
• 1446247-83-1 methyl 3-[({[4-cyano-3-(4-nitrophenyl)isothiazol-5-yl]amino}carbonyl)amino]propanoate 

Relevant academic research and scientific papers

NOVEL OXIDATION COLOR DEVELOPABLE COMPOUND AND OXIDATION COLOR DEVELOPMENT REAGENT

The present invention pertains to: an oxidation color developable compound that is represented by general formula (1), that has excellent solubility in water, and that is less affected by a substance coexisting in a sample; and an oxidation color development reagent using the oxidation color developable compound. In general formula (I), R1, R2, R3, and R4 each represent a straight-chain or branched alkyl group having 1-6 carbon atoms, X represents a hydrophilic functional group, and L represents —(CH2)j— (j represents an integer of 2-10), —(CH2CH2O)k— (k represents an integer of 1-10), or —(CH2)m—Z—(CH2)n— (m and n each independently represent an integer of 1-10, and Z represents —N+(CH3)2—, —CONH—, —NHCO—, —COO—, —OCO—, —NHCOO—, —OCONH—, —NHCONH—, and —(CH2NHCO)q—).

Synthesis of N-Acylamino-Acid Derivatives of Cytisine

N-acylamino-acid derivatives of cytisine were prepared by reacting cytisine with methyl esters of aminoacid isocyanates.

Organosilicon synthesis of isocyanates: III. Synthesis of aliphatic, carbocyclic, aromatic, and alkylaromatic isocyanatocatboxylic acid esters

A series of aminoacid esters was prepared by treating the aminoacid suspensions in ethanol with thionyl chloride. Best conversion of aminoacid esters to corresponding isocyanates was achieved in the case of aromatic and carbocyclic aminoesters by phosgeneation of their N-silyl derivatives, and in the case of aliphatic and alkylaromatic aminoesters by phosgeneation of O-silyl or N,O-bissilylurethanes on their basis. In the last case additional step of esterification of the by-products isocyanatoalkylcarboxylic acid chlorides is required after phosgeneation. Unusual generation of cynnamates and intramolecular N→O-migration of trimethylsilyl group in the solutions of silylated alkylaromatic β-aminoacid esters were found. Pleiades Publishing, Inc., 2006.

Maytansinoids, pharmaceutical compositions thereof and method of use thereof

Novel maytansinoids of the formula: STR1 wherein X is H or Cl, and R is STR2 wherein R1 and R2 may be the same or different, and each is H or a substituted or unsubstituted hydrocarbon residue or heterocyclic group, or R1 and R2 may, taken together with the adjacent N atom, form a heterocyclic group, and R3 is a substituted or unsubstituted hydrocarbon residue, have antimitotic, antitumor and antimicrobial activities.

Demethyl maytansinoids

Novel demethylmaytansinoids representable by the formula: STR1 [wherein X is Cl or H; R1 is H or acyl group] are produced from maytansinoids by means of enzymic transformation. The demethylmaytansinoids are useful as antifungal, antiprotozoal or antitumor agents.