50839-95-7Relevant academic research and scientific papers
SYNTHESIS OF 3-AMINO-2-CHLORO-4-METHYLPYRIDINE FROM ACETONE AND ETHYL CYANOACETATE
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Page/Page column 5, (2010/02/14)
A method for making 3-amino-2-chloro-4-methylpyridine from acetone and ethyl cyanoacetate, as depicted in the following reaction scheme.
Regioselective synthesis of 2-chloro 3-pyridinecarboxylates
Zhang,Stout,Keay,Scriven,Toomey,Goe
, p. 13177 - 13184 (2007/10/03)
2-Chlorocyanoacetate was found to undergo base-catalyzed Michael addition to α,β-unsaturated ketones or aldehydes to afford 5-oxopentenenitrile derivatives. In the presence of anhydrous HCl, these compounds cyclize to yield 2-chloro-3-pyridinecarboxylates. The process is highly regiospecific and useful in the synthesis of 2,3-disubstituted pyridines.
