5084-98-0

Basic information

• Product Name: Z-LEU-GLY-OME
• Synonyms: Z-LEUCYL-L-GLYCINE METHYL ESTER;Z-LEU-GLY-OME;N-CBZ-LEU-GLY METHYL ESTER;N-(N-Phenylmethoxycarbonyl-L-leucyl)glycine methyl ester;2-[[2-(benzyloxycarbonylamino)-4-methyl-pentanoyl]amino]acetic acid methyl ester;methyl 2-[[4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]acetate;methyl 2-[[4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]ethanoate
• CAS NO: 5084-98-0
• Molecular Formula: C₁₇H₂₄N₂O₅
• Molecular Weight: 336.38
• Mol File: 5084-98-0.mol

Chemical Properties

• Boiling Point: 516.4 °C at 760 mmHg
• Flash Point: 266.1 °C
• Appearance: /
• Density: 1.146 g/cm³
• Vapor Pressure: 9.01E-11mmHg at 25°C
• Refractive Index: 1.513
• Storage Temp.: -15°C
• CAS DataBase Reference: Z-LEU-GLY-OME(CAS DataBase Reference)
• NIST Chemistry Reference: Z-LEU-GLY-OME(5084-98-0)
• EPA Substance Registry System: Z-LEU-GLY-OME(5084-98-0)

Safety Data

• Hazardous Substances Data: 5084-98-0(Hazardous Substances Data)

Usage

Uses

Used in Biochemical Research:
Z-Leu-Gly-Ome is used as a substrate for enzyme-catalyzed reactions, particularly in the study of proteolytic enzymes such as elastase and cathepsin G. This application aids in understanding the mechanisms and functions of these enzymes, which are crucial in various biological processes.
Used in Pharmaceutical Development:
Z-Leu-Gly-Ome is used as a potential candidate for the development of new drugs targeting proteolytic enzymes. By studying its interactions with these enzymes, researchers can gain insights into the design of more effective therapeutic agents for treating diseases associated with abnormal proteolytic activity.
Used in Diagnostic Applications:
Z-Leu-Gly-Ome can be used as a diagnostic tool to assess the activity of proteolytic enzymes in biological samples. This can help in the early detection and monitoring of diseases where these enzymes play a significant role, such as certain types of cancer and inflammatory conditions.
Used in Educational Purposes:
Z-Leu-Gly-Ome is used as a teaching aid in academic institutions to demonstrate the principles of enzyme kinetics and the role of substrates in enzyme-catalyzed reactions. This helps students understand the fundamental concepts of biochemistry and the importance of proteolytic enzymes in various biological processes.

InChI:InChI=1/C17H24N2O5/c1-12(2)9-14(16(21)18-10-15(20)23-3)19-17(22)24-11-13-7-5-4-6-8-13/h4-8,12,14H,9-11H2,1-3H3,(H,18,21)(H,19,22)

Upstream product

• 2018-66-8 Z-Leu-OH 
• 501-53-1 benzyl chloroformate 
• 61-90-5 L-leucine 
• 3397-35-1 Z-L-leucine hydroxysuccinimide ester 
• 5680-79-5 glycine ethyl ester hydrochloride 
• 87024-12-2 (S)-1-(2'-benzyloxycarbonylamino-4'-methylpentanoyl)-3,5-dimethylpyrazole 
• 616-34-2 methoxycarbonylmethylamine 
• 53363-87-4 N-(benzyloxycarbonyl)leucine dicyclohexylamine salt 

Downstream Products

• 1361509-42-3 (S)-methyl 2-(2-(benzyloxycarbonylamino)-4-methylpentaneselenoamido)acetate 
• 107540-40-9 Ac-Leu-2-Ala-Ser-Leu-Gly-OMe 
• 107540-39-6 {(S)-2-[(S)-2-Amino-3-(diphenoxy-phosphoryloxy)-propionylamino]-4-methyl-pentanoylamino}-acetic acid methyl ester; hydrochloride 
• 107540-38-5 Z-Ser-Leu-Gly-OMe 
• 107540-60-3 Tr-Ser-Leu-Gly-OMe 
• 107540-59-0 Z-Ser(O-mesyl)-Leu-Gly-OMe 
• 107540-61-4 Tr-Azy-Leu-Gly-OMe 
• 107540-26-1 Z-Ser-Leu-Gly-OMe 
• 19739-60-7 Cbz-leucylglycyl hydrazide 
• 108061-14-9 [5-(1-Benzyloxycarbonylamino-3-methyl-butyl)-tetrazol-1-yl]-acetic acid methyl ester 
• 2706-38-9 N-(N-benzyloxycarbonyl-L-leucyl)-glycine 

Relevant articles and documents

Recyclable hypervalent iodine(III) reagent iodosodilactone as an efficient coupling reagent for direct esterification, amidation, and peptide coupling

A hypervalent iodine(III) reagent plays a novel role as an efficient coupling reagent to promote the direct condensation between carboxylic acids and alcohols or amines to provide esters, macrocyclic lactones, amides, as well as peptides without racemization. The regeneration of iodosodilactone (1) can also be readily achieved. The intermediate acyloxyphosphonium ion C from the activation of a carboxylic acid is thought to be involved in the present esterification reaction.

Synthesis of selenoxo peptides and oligoselenoxo peptides employing LiAlHSeH

Synthesis of selenoxo peptides by the treatment of Nα- protected peptide esters with a combination of PCl5 and LiAlHSeH is delineated. The method is simple, high-yielding, and free from racemization. Thus obtained selenoxo peptides are used as units for N-terminal chain extension through Nα-deprotection/coupling to yield peptide-selenoxo peptide hybrids. Multiple selenation is demonstrated by conversion of two peptide bonds of tripeptides into selenoxo peptide bonds. Amino acid derived arylamides are also converted into aryl selenoamides. C6H 5-CSeNH-Val-OMe 8f is obtained as single crystal, and its structure was determined through X-ray diffraction study.

SYNTHESIS OF FRAGMENTS OF THE VP1 PROTEIN OF TYPE A22 FOOT-AND-MOUTH DISEASE VIRUS. SYNTHESIS OF FRAGMENTS 134-139, 134-145, 140-145, 150-155, AND 150-159

Fragments of peptides of the amino acid sequences (134-145) and (150-159) of the VP1 protein of the type A22 foot-and-mouth disease (FMD)virus have been synthesized by the classical methods of peptide chemistry.Oligopeptides were obt

KINETICS OF THE ALKALINE HYDROLYSIS OF SEVERAL N-BENZYLOXYCARBONYLDIPEPTIDE METHYL AND ETHYL ESTERS

The reaction rates of the alkaline hydrolysis of synthesized N-protected dipeptide methyl and ethyl esters were studied systematically.From the kinetic data the energies of activation, the pre-exponential factors and the reference values at 40 deg C were calculated.The rate of hydrolysis shows to be strongly dependent on the C-terminal amino acid in the sequence Gly >> Ala/Met/Phe > Leu >> Val/Pro.Surprisingly the N-terminal amino acid also exerts an effect, but in a different sequence.N-Terminal Phe in particular shows a relative accelerating effect.Remarkable is the significantly faster ester hydrolysis of glycine containing dipeptide ethyl esters in ethanol/water compared to the corresponding methyl esters in methanol/water.