50846-18-9

Upstream product

• 24654-50-0 α-chloro-β-(4-methylthio-phenyl)propionitrile 
• 50846-17-8 trans-p-Thiocyanato-zimtsaeurenitril 
• 74-88-4 methyl iodide 
• 2987-46-4 4-thiocyanatoaniline 
• 62-53-3 aniline 
• 104-96-1 4-methylsulfanylaniline 
• 773837-37-9 sodium cyanide 
• 50846-16-7 1-Chlor-1-cyano-2-p-thiocyanatophenylethan 

Downstream Products

• 134731-38-7 1-(4-fluorophenyl)-4,5-dihydro-5-[4-(methylthio)phenyl]-3-pyrazolamine 
• 134729-77-4 1-(4-fluorophenyl)-5-[4-(methylthio)phenyl]pyrazole 
• 134731-39-8 1-(4-fluorophenyl)-5-[4-(methylthio)phenyl]-3-pyrazolamine 
• 134731-22-9 3-bromo-1-(4-fluorophenyl)-5-[4-(methylthio)phenyl]pyrazole 
• 193422-46-7 1-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]-3-pyrazolamine 

Relevant academic research and scientific papers

CUCN-MEDIATED ONE POT PRODUCTION OF CINNAMONITRILE DERIVATIVES

The present invention discloses a cheaper and practical protocol for the construction of a wide variety of o-cyanocin-namonitrile and their structural analogues that proceeds with good yields in a single step using CuCN as the only reagent.

Cu-catalyzed debrominative cyanation of gem-dibromoolefins: A facile access to α,β-unsaturated nitriles

An efficient catalytic route for the synthesis of α,β-unsaturated nitriles from easily accessible gem-dibromoolefins has been developed. The method utilized inexpensive reagents such as Cu2O as a catalyst, l-proline as a ligand and NaCN as a cyanide source to afford α,β-unsaturated nitriles in high yields (62-86%). A deuterium exchange study has shown that one of the bromide atoms of gem-dibromoolefins exchanges with cyanide while the other with a deuterium atom.

CUCN-MEDIATED ONE POT PRODUCTION OF CINNAMONITRILE DERIVATIVES

The present invention discloses a cheaper and practical protocol for the construction of a wide variety of o-cyanocinnamonitrile and their structural analogues that proceeds with good yields in a single step using CuCN as the only reagent.