50867-11-3

Basic information

• Product Name: (8R,9S,13S,14S,17R)-13-Methyl-17-((E)-2-triphenylsilanyl-vinyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol
• Synonyms: (8R,9S,13S,14S,17R)-13-Methyl-17-((E)-2-triphenylsilanyl-vinyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol
• CAS NO: 50867-11-3
• Molecular Weight: 556.82
• Mol File: 50867-11-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (8R,9S,13S,14S,17R)-13-Methyl-17-((E)-2-triphenylsilanyl-vinyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol(CAS DataBase Reference)
• NIST Chemistry Reference: (8R,9S,13S,14S,17R)-13-Methyl-17-((E)-2-triphenylsilanyl-vinyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol(50867-11-3)
• EPA Substance Registry System: (8R,9S,13S,14S,17R)-13-Methyl-17-((E)-2-triphenylsilanyl-vinyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol(50867-11-3)

Safety Data

• Hazardous Substances Data: 50867-11-3(Hazardous Substances Data)

Upstream product

• 57-63-6 ethinyl estradiol 
• 789-25-3 HSiPh₃ 

Relevant articles and documents

Steroidal Silicon Side-Chain Analogues as Potential Antifertility Agents

A number of silicon-substituted analogues of ethynylestradiol that exhibit modified and enhanced biological activities have been synthesized.Particularly noteworthy are a group of estradiol analogues that exhibit high antifertility potency and markedly reduced estrogenic activity.The best compounds synthesized are 17α-estradiol (5) and 17α-estradiol (33), which show a separation of antifertility from estrogenic activity in the rat.The results of structure-activity studies indicate a good correlation between the observed biological activities and the calculated van der Waals volumes of the three variable silicon substituents.