50877-40-2Relevant academic research and scientific papers
A mild halogenation of pyrazoles using sodium halide salts and Oxone
Olsen, Kathryn L.,Jensen, Matthew R.,MacKay, James A.
supporting information, p. 4111 - 4114 (2017/09/29)
A mild, inexpensive, and operationally simple pyrazole halogenation method utilizing Oxone and sodium halide salts is reported. This work documents 17 examples of alkyl, aryl, allyl, and benzyl substituted 4-chloro and 4-bromopyrazoles, obtained in up to 93% yield. Reactions are performed in water under ambient conditions and generation of organic byproducts is avoided.
Rapid Synthesis of Aryl Fluorides in Continuous Flow through the Balz–Schiemann Reaction
Park, Nathaniel H.,Senter, Timothy J.,Buchwald, Stephen L.
supporting information, p. 11907 - 11911 (2016/11/17)
The Balz–Schiemann reaction remains a highly utilized means for preparing aryl fluorides from anilines. However, the limitations associated with handling aryl diazonium salts often hinder both the substrate scope and scalability of this reaction. To address this, a new continuous flow protocol was developed that eliminates the need to isolate the aryl diazonium salts. The new process has enabled the fluorination of an array of aryl and heteroaryl amines.
