50878-44-9

Upstream product

• 62558-05-8 2,2-dimethyl-1-(4-nitrophenyl)propan-1-one 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 71-43-2 benzene 
• 19262-20-5 (1,2,2-Trimethyl-propyl)-benzene 
• 464-07-3 3,3-dimethyl-2-butanol 
• 40637-42-1 4-(1-chloro-1,2,2-trimethylpropyl)nitrobenzene 
• 40637-44-3 1-nitro-4-(1,2,2-trimethylpropyl)benzene 

Relevant academic research and scientific papers

Formation by SRN1 reactions and 1H N.M.R. properties of sterically encumbered 2,4,6-triaIkyIphenyl p-nitrobenzyl sulfides

Sterically hindered p-nitrobenzylic chlorides (1) and (2) react with the sodium salts of 2,4,6-trialkylbenzenethiols (3a)-(5a) by the SRN1 reaction to give good yields of the corresponding p-nitrobenzylic aryl sulfides (6)-(10). For example, th

Distal Stereocontrol Using Guanidinylated Peptides as Multifunctional Ligands: Desymmetrization of Diarylmethanes via Ullman Cross-Coupling

We report the development of a new class of guanidine-containing peptides as multifunctional ligands for transition-metal catalysis and its application in the remote desymmetrization of diarylmethanes via copper-catalyzed Ullman cross-coupling. Through design of these peptides, high levels of enantioinduction and good isolated yields were achieved in the long-range asymmetric cross-coupling (up to 93:7 er and 76% yield) between aryl bromides and malonates. Our mechanistic studies suggest that distal stereocontrol is achieved through a Cs-bridged interaction between the Lewis-basic C-terminal carboxylate of the peptides with the distal arene of the substrate.