50892-14-3Relevant academic research and scientific papers
Tuning Nuclear Receptor Selectivity of Wy14,643 towards Selective Retinoid X Receptor Modulation
Pollinger, Julius,Gellrich, Leonie,Schierle, Simone,Kilu, Whitney,Schmidt, Jurema,Kalinowsky, Lena,Ohrndorf, Julia,Kaiser, Astrid,Heering, Jan,Proschak, Ewgenij,Merk, Daniel
supporting information, p. 2112 - 2126 (2019/03/08)
The fatty acid sensing nuclear receptor families retinoid X receptors (RXRs) and peroxisome proliferator-activated receptors (PPARs) hold therapeutic potential in neurodegeneration. Valuable pleiotropic activities of Wy14,643 in models of such conditions
Compounds, compositions and methods for modulating beta-amyloid production
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, (2008/06/13)
Methods and compositions useful in the treatment of amyloidosis and conditions and diseases associated therewith, such as Alzheimer's disease, are provided. The methods involve administering to a subject in need thereof a pharmaceutical composition including one or more agents that modulate PPARα and/or PPARδ activity, resulting in an inhibition of β-amyloid production and/or release from cells of the subject, particularly brain cells.
Compounds, compositions and methods for modulating beta-amyloid production
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, (2008/06/13)
Methods and compositions useful in the treatment of amyloidosis and conditions and diseases associated therewith, such as Alzheimer's disease, are provided. The methods involve administering to a subject in need thereof a pharmaceutical composition includ
2-PYRIMIDINYLTHIO)ALKANOIC ACIDS, ESTERS, AMIDES AND HYDRAZIDES
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, (2008/06/13)
(2-Pyrimidinylthio)alkanoic acid, esters, amides and hydrazides as well as various 4- and 6-substituted derivatives thereof as depicted by the structural formula: SPC1 In which R and R2 are independently --H or lower alkyl; R1 is --H
