50892-49-4Relevant articles and documents
Molecular determinants for improved activity at PPARα: Structure-activity relationship of pirinixic acid derivatives, docking study and site-directed mutagenesis of PPARα
Lamers, Christina,Dittrich, Michaela,Steri, Ramona,Proschak, Ewgenij,Schubert-Zsilavecz, Manfred
, p. 4048 - 4052 (2014)
Peroxisome proliferator-activated receptors (PPARs) are attractive targets for the treatment of the metabolic syndrome. Especially a combination of PPARα and PPARγ agonistic activity seems worthwhile to be pursued. Herein we present the design and synthes
Molecular determinants for improved activity at PPARα: Structure-activity relationship of pirinixic acid derivatives, docking study and site-directed mutagenesis of PPARα
Lamers, Christina,Dittrich, Michaela,Steri, Ramona,Proschak, Ewgenij,Schubert-Zsilavecz, Manfred
supporting information, p. 4048 - 4052 (2015/03/14)
Peroxisome proliferator-activated receptors (PPARs) are attractive targets for the treatment of the metabolic syndrome. Especially a combination of PPARα and PPARγ agonistic activity seems worthwhile to be pursued. Herein we present the design and synthes
Design, synthesis, and biological evaluation of a novel class of γ-secretase modulators with pparγ activity
Hieke, Martina,Ness, Julia,Steri, Ramona,Dittrich, Michaela,Greiner, Christine,Werz, Oliver,Baumann, Karlheinz,Schubert-Zsilavecz, Manfred,Weggen, Sascha,Zettl, Heiko
supporting information; experimental part, p. 4691 - 4700 (2010/10/03)
We present a novel class of dual modulators of γ-secretase and peroxisome proliferator-activated receptor γ (PPARγ) based on the structure of 2-(bis(phenethoxy)pyrimidine-2-ylthio)hexanoic acid 8 (IC 50(Aβ42) = 22.8 μM, EC50(PPARγ) =