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Aconine is an alkaloid originally isolated from Aconitum species and is an active metabolite of aconitine. It possesses neurotoxin properties, activating tetrodotoxin-sensitive Na+ channels, which leads to presynaptic depolarization and the blocking of nerve action potential. This, in turn, inhibits the release of neurotransmitters and decreases the end plate potential at the neuromuscular junction. Aconine also exhibits inhibitory effects on osteoclast differentiation and bone resorption in a concentration-dependent manner, as well as suppressing RANKL-induced activation of NF-κB and NFATc1 in RAW 264.7 cells.

509-20-6

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509-20-6 Usage

Uses

Used in Pharmaceutical Applications:
Aconine is used as a neurotoxin for its ability to activate tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization and blocking nerve action potential. This property makes it a potential candidate for the development of drugs targeting neurological disorders and pain management.
Used in Orthopedic Applications:
Aconine is used as an inhibitor of osteoclast differentiation and bone resorption in a concentration-dependent manner. Its ability to suppress RANKL-induced activation of NF-κB and NFATc1 in RAW 264.7 cells makes it a potential therapeutic agent for the treatment of bone-related diseases, such as osteoporosis and bone metastasis in cancer patients.
Used in Research Applications:
Aconine is used as a research tool for studying the mechanisms of action of neurotoxins and their effects on neurotransmitter release and neuromuscular junction function. Additionally, its inhibitory effects on osteoclast differentiation and bone resorption make it a valuable compound for investigating the molecular pathways involved in bone metabolism and the development of novel therapeutic strategies for bone-related diseases.

Toxicity

In vivo, aconine is toxic to mice when administered intravenously at a dose of 120 mg/kg.?It induces flaccid paralysis and toxicity in rats with toxic dose (TD50) and LD50 values of 1.5 and 1.7 μmol per animal, respectively.

Check Digit Verification of cas no

The CAS Registry Mumber 509-20-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,0 and 9 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 509-20:
(5*5)+(4*0)+(3*9)+(2*2)+(1*0)=56
56 % 10 = 6
So 509-20-6 is a valid CAS Registry Number.
InChI:InChI=1/C25H41NO9/c1-6-26-9-22(10-32-2)12(27)7-13(33-3)24-11-8-23(30)19(28)14(11)25(31,20(29)21(23)35-5)15(18(24)26)16(34-4)17(22)24/h11-21,27-31H,6-10H2,1-5H3/t11-,12?,13?,14-,15?,16?,17-,18-,19?,20?,21?,22?,23-,24?,25-/m1/s1

509-20-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name Aconine

1.2 Other means of identification

Product number -
Other names Aconitane-3,8,13,14,15-pentol, 20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-, (1-,3-,6-,14-,15-,16α)-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:509-20-6 SDS

509-20-6Downstream Products

509-20-6Relevant academic research and scientific papers

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