509-72-8

Usage

Uses

Used in Biomedical Research:
Fluoran, 3,6-diaminois used as a fluorescent marker for labeling nucleic acids and proteins in microscopy and flow cytometry. Its application in this field is crucial for studying the structure and function of nucleic acids, as well as visualizing and tracking the movement of biological molecules in living cells.
Used in Diagnostic Applications:
In the medical industry, Fluoran, 3,6-diaminois utilized as a diagnostic tool in various tests and assays that require the detection and analysis of nucleic acids. Its fluorescent properties make it an effective marker for identifying and quantifying specific genetic sequences or molecular interactions.
Used in Drug Development:
Fluoran, 3,6-diaminocan be employed in the development of new drugs targeting nucleic acid-related diseases. Its ability to bind to DNA and RNA makes it a potential candidate for the design of drugs that modulate gene expression or interfere with the replication of pathogens.
Used in Environmental Monitoring:
In environmental science, Fluoran, 3,6-diaminocan be used as a tracer to monitor the presence and distribution of nucleic acids in various ecosystems. This can help in understanding the role of microorganisms in environmental processes and assessing the impact of pollutants on microbial communities.

Upstream product

• 85-44-9 phthalic anhydride 
• 591-27-5 m-Hydroxyaniline 
• 121-47-1 3-aminobenzenesulfonic acid 
• 509-34-2 rhodamine B 

Downstream Products

• 2321-07-5 fluorescein 
• 1140465-77-5 N,N'-Boc-Hph-rhodamine 110 
• 897929-08-7 3'-amino-6'-(tert-butoxycarbonylamino)spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one 
• 628302-72-7 N-Mor-rhodamine 110 
• 1311393-87-9 C₂₅H₁₉N₅O₅ 
• 1027627-68-4 azido-Rh₁₁₀-t-Boc 
• 1346550-28-4 C₃₅H₂₈N₄O₁₀ 
• 1346550-26-2 C₃₀H₂₇N₃O₆ 
• 1346550-27-3 C₂₅H₁₉N₃O₄ 
• 1429788-65-7 C₃₂H₃₂N₄O₇S₂ 
• 1433896-28-6 rhodamine(Arg-(CBz)2-NHBoc)₂ 

Relevant academic research and scientific papers

Atomically Conformal Metal Laminations on Plasmonic Nanocrystals for Efficient Catalysis

Despite the enormous application potential, methods for conformal few-atomic-layer deposition on colloidal nanocrystals (NCs) are scarce. Similar to the process of lamination, we introduce a confine and shine strategy to homogeneously modify the different surface curvatures of plasmonic NCs with ultrathin conformal layers of diverse catalytic noble metals. This self-limited epitaxial skinlike metal growth harvests the localized surface plasmon resonance to induce reduction chemistry directly on the NC surface, confined inside hollow silica. This strategy avoids any kinetic anisotropic metal deposition. Unlike the conventional thick, anisotropic, and dendritic shells, which show severe nonradiative damping, the skinlike metal lamination preserves the key plasmonic properties of the core NCs. Consequently, the plasmonic-catalytic hybrid nanoreactors can carry out a variety of organic reactions with impressive rates.

Rhodamine-based fluorogenic probe for imaging biological thiol

We have developed a new fluorescent probe for biological thiol. The probe was synthesized by the modification of the 2,4-dinitrobenzenesulfonyl group with rhodamine 110. The selective detection of thiol species such as cysteine or glutathione was achieved in biological conditions. Moreover, the probe was successfully applied to the imaging of thiol species in living human cells.

Triarylmethane Fluorophores Resistant to Oxidative Photobluing

Spectral stability of small-molecule fluorescent probes is required for correct interpretation and reproducibility of multicolor fluorescence imaging data, in particular under high (de)excitation light intensities of super-resolution imaging or in single-molecule applications. We propose a synthetic approach to a series of spectrally stable rhodamine fluorophores based on sequential Ru- and Cu-catalyzed transformations, evaluate their stability against photobleaching and photoconversion in the context of other fluorophores using chemometric analysis, and demonstrate chemical reactivity of fluorophore photoproducts. The substitution patterns providing the photoconversion-resistant triarylmethane fluorophores have been identified, and the applicability of nonbluing labels in live-cell STED nanoscopy is demonstrated.