50907-20-5

Usage

Uses

Used in Pharmaceutical Industry:
5-(3-Fluorophenyl)-1H-tetrazole is used as a pharmaceutical intermediate for the synthesis of various drugs. Its unique structure and properties make it a valuable component in the development of new medications.
Used in Chemical Synthesis:
TFMFPT is used as a reagent in chemical synthesis processes. Its ability to act as a ligand in coordination chemistry allows it to facilitate the formation of new compounds and contribute to the advancement of chemical research.
Used in Research and Development:
5-(3-Fluorophenyl)-1H-tetrazole is utilized in research and development as a component in various scientific studies. Its potential biological activities and applications in different fields make it an interesting subject for researchers in pharmaceutical and biomedical fields.
Used in Medicine:
TFMFPT may have uses in the medical field due to its potential biological activities. Its ability to act as a ligand and its unique structure make it a promising candidate for the development of new therapeutic agents.
Used in Agriculture:
5-(3-Fluorophenyl)-1H-tetrazole may also find applications in agriculture, where it could be used as a component in the development of new agrochemicals or as a tool in agricultural research.
Used in Material Science:
TFMFPT has potential applications in material science, where its unique properties could be harnessed to develop new materials with specific characteristics or functions.

InChI:InChI=1/C7H5FN4/c8-6-3-1-2-5(4-6)7-9-11-12-10-7/h1-4H,(H,9,10,11,12)

Upstream product

• 624-84-0 formic acid hydrazide 
• 403-54-3 m-Fluorobenzonitrile 

Downstream Products

• 1077627-07-6 ethyl (Z)-3-[5-(3-fluorophenyl)-1H-tetrazol-1-yl]propenoate 
• 1077626-99-3 ethyl (E)-3-[5-(3-fluorophenyl)-1H-tetrazol-1-yl]propenoate 

Relevant academic research and scientific papers

Synthesis of 5-Substituted 1H-Tetrazoles Catalyzed by M-SAPO-34 (M = Co, Cu, Mn, Fe, and V) Nanostructures

Abstract: The synthesis of 5-substituted 1H-tetrazoles by use of a series of M-SAPO-34 (M = Co, Cu, Mn, Fe, and V) nanocatalysts are presented. Following the optimized conditions, Co-SAPO-34 nanocatalyst has been found to effectively catalyze the 5-substi

Triple reuptake inhibitors: Design, synthesis and structure–activity relationship of benzylpiperidine–tetrazoles

Monoamine transporters are important targets in the treatment of various central nervous disorders. Several limitations of traditional reuptake inhibitors, like delayed onset of action, insomnia, and sexual dysfunction, have compelled the search for safer, more effective compounds. In this study, we have sought to identify novel monoamine reuptake inhibitors. Based upon the docking study of compounds that we had reported previously, aromatic rings (A1) were modified to generate a novel series of benzylpiperidine–tetrazoles. Thirty-one compounds were synthesized and evaluated for their triple reuptake inhibition of serotonin, norepinephrine and dopamine. Triple reuptake inhibitor, compound 2q, in particular, showed potent serotonin reuptake inhibition, validating our design approach.

Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: Structure-activity relationship and mechanism of action

CRM1-mediated nucleocytoplasmic transport plays an important role in many cellular processes and diseases. To investigate the structural basis required for the inhibition of the CRM1-mediated nuclear export we have synthesized analogs of a previously identified small molecule lead compound and monitored their activity against the Rev function of the human immunodeficiency virus. Microscopy studies show that the active congeners of this series inhibit the nucleocytoplasmic transport of Rev and the co-localization between Rev and CRM1 in living cells. Mechanism of action studies show their interaction with the Cys528 residue of CRM1 involving a Michael-addition type of reaction. However, structure-activity relationship demonstrates strict constraints to the structure of the inhibitors, and shows that activity is not solely correlated to Michael-addition suggesting a more complex mechanism of action. Our results are suggestive for the existence of a well-defined interaction at the CRM1-NES binding site. In addition, the most selective congener inhibited the HIV-1 production in latently infected cells. These specific CRM1 inhibitors are of interest as tool for analyzing the mechanisms of post-transcriptional control of gene expression and provide insight in the design of new agents.

A Practical Synthesis of 5-Substituted Tetrazoles.

Nitrosation of N-formyl amidrazones 8a-g with sodium nitrite - aqueous hydrochloric acid gives tetrazoles 10a-g in good yields.