50907-57-8

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-6-nitrobenzenemethanol is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique chemical structure allows it to be a versatile building block for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, 2-Chloro-6-nitrobenzenemethanol is utilized as an intermediate for the synthesis of various agrochemicals, including pesticides and herbicides. Its potential as an antifungal and antibacterial agent makes it a valuable component in the development of effective crop protection products.
Used in Organic Synthesis:
2-Chloro-6-nitrobenzenemethanol is used as a building block in the synthesis of other organic compounds. Its reactivity and functional groups make it a useful precursor for the preparation of various organic molecules with diverse applications in different industries.
Used as Antifungal and Antibacterial Agent:
2-Chloro-6-nitrobenzenemethanol has potential applications as an antifungal and antibacterial agent. Its ability to inhibit the growth of fungi and bacteria makes it a promising candidate for use in various applications, such as in the development of antimicrobial coatings, disinfectants, and preservatives.

InChI:InChI=1/C7H6ClNO3/c8-6-2-1-3-7(9(11)12)5(6)4-10/h1-3,10H,4H2

Upstream product

• 56433-01-3 2-chloro-6-nitrobenzyl bromide 
• 83-42-1 6-chloro-2-nitrotoluene 
• 6361-22-4 2-chloro-6-nitrobenzaldehyde 

Downstream Products

• 6361-22-4 2-chloro-6-nitrobenzaldehyde 
• 5344-49-0 2-chloro-6-nitrobenzoic acid 
• 258842-75-0 2-chloro-6-nitrobenzyl methanesulfonate 
• 193970-86-4 C₂₁H₅ClF₁₀N₄O₅S 
• 56433-01-3 2-chloro-6-nitrobenzyl bromide 
• 89892-65-9 2,β-Dinitro-6-chlor-styrol 
• 206882-41-9 5-(2-chloro-6-nitrobenzyloxy)isoquinoline 
• 206883-06-9 5-(2-amino-6-chlorobenzyloxy)isoquinoline 
• 206884-02-8 5-(2-amino-3,6-dichlorobenzyloxy)isoquinoline 

Relevant academic research and scientific papers

IRIDIUM-BASED CATALYSTS FOR HIGHLY EFFICIENT DEHYDROGENATION AND HYDROGENATION REACTIONS IN AQUEOUS SOLUTION AND APPLICATIONS THEREOF

A series of iridium-based catalysts for dehydrogenation of formic acid, and hydrogenation using formic acid as the hydrogen source, and the process using the catalyst(s) to produce hydrogen gas from formic acid solution, or to reduce aldehydes using formic acid, are disclosed and claimed. More specifically, the present invention relates to a group of pentamethylcyclopentadienyl (Cp*) iridium complexes with different Ν,Ν-bidentate ligands that catalyze dehydrogenation from formic acid, and chemo-selective hydrogenation of aldehydes, in the aqueous solution system in a highly efficient, and long life-time manner.

Iridium-catalyzed highly efficient chemoselective reduction of aldehydes in water using formic acid as the hydrogen source

A water-soluble highly efficient iridium catalyst is developed for the chemoselective reduction of aldehydes to alcohols in water. The reduction uses formic acid as the traceless reducing agent and water as a solvent. It can be carried out in air without the need for inert atmosphere protection. The products can be purified by simple extraction without any column chromatography. The catalyst loading can be as low as 0.005 mol% and the turn-over frequency (TOF) is as high as 73 800 mol mol-1 h-1. A wide variety of functional groups, such as electron-rich or deficient (hetero)arenes and alkenes, alkyloxy groups, halogens, phenols, ketones, esters, carboxylic acids, cyano, and nitro groups, are all well tolerated, indicating excellent chemoselectivity.

Method for producing 2-halo-6-nitrobenzoic acids

The present invention relates to a process for the preparation of 2-halo-6-nitrobenzoic acids by oxidation of 2-halo-6-nitro-benzyl alcohols, esters, ethers, or mixtures thereof with nitric acid and to the use of this process as a step in the preparation of 2-halo-6-nitrobenzoic acids from 2-halo-6-nitrotoluenes.

AMINE DERIVATIVES

A compound of the formula: ???whereinX and X' are the same or different, and each represents a hydrogen atom, a fluorine atom, a chlorine atom or an amino optionally having substituents, and at least one of X and X' represents a fluorine atom, a chlorine atom or an amino optionally having substituents;R1 and R2 represent a hydrogen atom or C1-6 alkyl optionally having substituents, or R1 and R2, together with the adjacent nitrogen atom, form a nitrogen-containing heterocyclic ring optionally having substituents;Y and Q are the same or different, and each represents a bond or a spacer having a main chain of 1 to 6 atoms;... represents a single bond or a double bond;T1 and T2 are the same or different, and each represents C(R9) (R9 represents a hydrogen atom, a hydroxy or C1-6 alkyl) or N, when each of the adjacent ... is a single bond, and C when the adjacent ... is a double bond; andAr represents an aromatic group optionally having substituents, a C3-9 cycloalkyl group optionally having substituents, a 3 to 9-membered saturated heterocyclic group optionally having substituents, a hydrogen atom or a halogen atom; provided that 6-chloro-3-(R,S)-(N,N-dimethylamino)methyl-1-[3-(indol-3-yl)-2-[(R)-(4-phenylpiperazin-1-yl)carbonylamino]propanoyl]-1,2,3,4-tetrahydroquinoline; 6-chloro-3-(R,S)-(N,N-dimethylamino)methyl-1-[3-(indol-3-yl)-2-[(R)-4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidinocarbonylamino]propanoyl]-1,2,3,4-tetrahydroquinoline and 1-benzoyl-N-[(R)-2-[6-chloro-3-[(N,N-dimethylamino)methyl]-1,2,3,4-tetrahydroquinolin-1-yl]-1-[3-(indol-3-yl)propanoyl]-4-piperidinecarboxamide are excluded; a salt thereof or a prodrug thereof has an excellent somatostatin receptor binding inhibition action and is useful for preventing and/or treating diseases associated with somatostatin.

Studies on anti-Helicobacter pylori agents. Part 1: Benzyloxyisoquinoline derivatives

The synthesis and optimization of the anti-Helicobacter pylori activity of a novel series of benzyloxyisoquinoline derivatives that was discovered by a random screening process, are described. In the in vitro assay, compound 10c containing a 3-acetamido-2,6-dichlorobenzyl substituent was found to have extremely potent activity against H. pylori and no activity against other common bacteria. The anti-H. pylori activity of 10c was superior to that of amoxicillin (AMPC) (1) and clarithromycin (CAM) (2). However, 10c did not show in vivo efficacy in a mouse infection model; a feature attributed to the lack of strong bactericidal activity at short contact times. (C) 1999 Elsevier Science Ltd.

BIOMIMETIC MODELS OF CYTOCHROME P-450. SYNTHESIS AND CATALYTIC ACTIVITY OF Mn-PORPHYRINS BEARING COVALENTLY ATTACHED AXIAL LIGANDS

A description is presented of the synthesis of Mn(III)-tetraarylporphyrins 4 and 5 in which a pyridine axial ligand is connected, through a flexible chain of linearly disposed 9 and 14 atoms, to the tetra(2,6-dichlorophenyl)porphyrin, 6, structure, which is particulary resistant to oxidative degradation.In 4a and 4b the chain is bonded to the porphyrin skeleton through an amido bond in the meta position of a meso-phenyl ring.These Mn(III)-porphyrins proved to be catalytically even more efficient than 6 in the HOCl alkene epoxidations carried out under CH2Cl2-H2O two-phase conditions, at pH 10.5 and in the absence of a phase-transfer catalyst.The chemical stability and catalytic activity of 4a and 4b are lowered in alkene epoxidations promoted by 30percent-H2O2 in the presence of benzoic acid.Mn(III)-porphyrins 5a and 5b, in which one out of eight chorine atoms of 6 has been replaced by the amido group bearing the flexible chain, were less stable with respect to 4a and 4b in epoxidations promoted by either HOCl or 30percent-H2O2.Coordiantion of anchored pyridine and factors ruling catalytic efficiency and chemical stability of catalysts 4 and 5 are also examined.

Mass Spectrometric Fragmentation Reactions. XXXI-The Fragmentation Behaviour of o-Halobenzoic Acids Substituted in the 5-Position: A Novel Ortho Effect

A fragmentation sequence typical for o-halobenzoic acids carrying a heteroatom substituent in the 5-position is described.