56433-01-3

Basic information

• Product Name: 2-(bromomethyl)-1-chloro-3-nitrobenzene
• Synonyms: 2-(bromomethyl)-1-chloro-3-nitrobenzene;6-Chloro-2-nitrobenzyl bromide;Einecs 260-179-8
• CAS NO: 56433-01-3
• Molecular Formula: C₇H₅BrClNO₂
• Molecular Weight: 250.4771
• EINECS: 260-179-8
• Mol File: 56433-01-3.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 295.6°C at 760 mmHg
• Flash Point: 132.6°C
• Appearance: /
• Density: 1.755
• Vapor Pressure: 0.00266mmHg at 25°C
• Refractive Index: 1.6110 (estimate)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-(bromomethyl)-1-chloro-3-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(bromomethyl)-1-chloro-3-nitrobenzene(56433-01-3)
• EPA Substance Registry System: 2-(bromomethyl)-1-chloro-3-nitrobenzene(56433-01-3)

Safety Data

• Hazardous Substances Data: 56433-01-3(Hazardous Substances Data)

Usage

Uses

2-(Bromomethyl)-1-chloro-3-nitrobenzene is a reactant in the synthesis of cyclic hydroxamic acid PF-04859989, a potent and selective inhibitor of human and rat Kynurenine aminotransferase II (KAT II) for treatment of schizophrenia.

InChI:InChI=1/C7H5BrClNO2/c8-4-5-6(9)2-1-3-7(5)10(11)12/h1-3H,4H2

Upstream product

• 50907-57-8 (2-chloro-6-nitrobenzene)methanol 
• 88-72-2 1-methyl-2-nitrobenzene 
• 83-42-1 6-chloro-2-nitrotoluene 
• 7726-95-6 bromine 

Downstream Products

• 56433-03-5 2-(6-Chlor-2-nitro-benzyl)-2-acetamino-malonsaeure-diethylester 
• 50907-57-8 (2-chloro-6-nitrobenzene)methanol 
• 6361-22-4 2-chloro-6-nitrobenzaldehyde 
• 95196-89-7 1-(2-chloro-6-nitro-benzyl)-pyridinium; bromide 
• 109319-74-6 N-(2-Chlor-6-nitrobenzyl)phthalimid 
• 919076-97-4 acetate of 2-chloro-6-nitrobenzyl alcohol 
• 89277-98-5 2-(2-chloro-6-nitrophenyl)acetonitrile 
• 1247021-83-5 diethyl (2-amino-6-chlorobenzyl)propanedioate 
• 72995-15-4 5-chloro-3,4-dihydro-2(1H)-quinolinone 
• 882023-24-7 2-oxo-1,2,3,4-tetrahydroquinoline-5-carbonitrile 
• 333954-56-6 diethyl 2-[(2-chloro-6-nitro-phenyl)methyl]propanedioate 
• 1256557-54-6 2-{[(2-chloro-6-nitrophenyl)methyl]sulfanyl}-6-methylpyrimidin-4-ol 
• 70018-53-0 N-(2-chloro-6-nitrobenzyl)-D-alanine ethyl ester 

Relevant articles and documents

NOVEL FUNGICIDAL CARBAMATE COMPOUNDS

An object of the present invention is to provide a carbamate compound or a salt thereof that controls diseases. The present invention provides a carbamate compound represented by Formula (1), or a salt thereof, wherein R1, R3 and R6 are identical or different and each represents hydrogen, or the like; R2 represents hydrogen, halogen, or C1-6 alkyl; R4 and R5 are identical or different and each represents hydrogen, or the like; R7 represents hydrogen, or the like; R8 represents hydrogen, or C1-6 alkyl; X and Χ1 independently represent oxygen, or sulfur; Y represents oxygen, or sulfur; Z represents oxygen/ or sulfur; l is an integer of 0 to 2; m is an integer of 0 to 3; n is an integer of 0 to 4; and when l, m or n is more than one, the l, m or n may be the same or different.

NEW DIHYDROQUINOLINE PYRAZOLYL COMPOUNDS

The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R15, R16, R17 and n are as described herein, compositions including the compounds and methods of using the compounds.

EP2/4 AGONISTS

EP2/4 compounds having improved dual pharmacological activity are described. The uniqueness of using EP2/4 dual agonists resides in their ability to modify both uveoscleral outflow via the ciliary muscle and conventional outflow via trabecular meshwork and Schlemm's canal all in the same treatment paradigm. The compounds can be employed for the treatment of glaucoma and ocular hypertension. Formula (I).