50932-22-4Relevant academic research and scientific papers
Palmatine and Berberine isolation artifacts
Marek, Radek,Seckarova, Pavlina,Hulova, Dagmar,Marek, Jaromir,Dostal, Jiri,Sklenar, Vladimir
, p. 481 - 486 (2003)
Some 8-substituted derivatives of the protoberberine alkaloids palmatine (1a) and berberine (1b) have been prepared and investigated by 1D and 2D NMR spectroscopy (H-1, C-13, N-15). Complete NMR data for the 8-hydroxy (2), 8-methoxy (3), 8-ethoxy (4), and
The Synthesis and Investigation of New Electroneutral Berberine Derivatives
Burov, Oleg N.,Demekhin, Oleg D.,Kletskii, Mikhail Е.,Kurbatov, Sergey V.,Lisovin, Anton V.,Zagrebaev, Alexander D.
, p. 45 - 57 (2022/02/09)
[Figure not available: see fulltext.] The possibility of obtaining electroneutral 8-substituted berberines was demonstrated experimentally as well as by DFT/B3LYP and ab initio MP2/HF quantum-chemical calculations with the 6-311+G(d,p) basis set. In alkaline media, it is possible to substitute the C-8 position of berberine with such C-nucleophiles as methyl ketones, acetic acid esters, nitriles, geminal di- and trihaloalkanes. This process proceeds stepwise. First, berberine is attacked by a hydroxide anion to form a covalently bonded 8-hydroxyberberine, then 8-hydroxyberberine reacts with a nucleophile in the nonionized (molecular) form.
HYDROPHILIC BERBERINE-TYPE DERIVATIVE AND APPLICATION THEREOF IN PREPARING DRUG
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Paragraph 0059, (2021/02/18)
An 8-dihalomethyl berberine-type quaternary ammonium salt compound represented by general formula (I) or (II) and an application thereof in preparing a drug. The compound shows hydrophilicity and has antimicrobial, anti-inflmmatory, anti-ulcerative colitis, and antitumor activities, while having no or low toxicity.
8-dihalo methylene dihydroberberine compound and anti-infection and anti-inflammatory application thereof
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Paragraph 0050-0051, (2019/11/12)
The invention discloses an 8-dihalo methylene dihydroberberine compound and anti-infection and anti-inflammatory application thereof, and specifically relates to the 8-dihalo methylene dihydroberberine compound shown as the general formula I and physiologically acceptable salt, a synthetic method and application in preparation of a product to prevent, relieve and/or treat microbial infections andinflammation of the 8-dihalo methylene dihydroberberine compound. Compared with a berberine alkaloid quaternary ammonium salt substrate, the 8-dihalo methylene dihydroberberine compound shows significantly enhanced antibacterial activity to gram-positive bacteria and fungus; and pharmacological activity intensity of the 8-dihalo methylene dihydroberberine compound is obviously higher than that ofa control drug, and the 8-dihalo methylene dihydroberberine compound has the advantages of non-toxicity or low toxicity at the same time and can be used for preparing the product to prevent, relieve and/or treat the microbial infections and inflammation.
13,13a-DIHYDROBERBERINE DERIVATIVES, THEIR PHARMACEUTICAL COMPOSITION AND USE
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Page/Page column 18, (2009/07/10)
The present invention provides 13,13a-dihydroberberine derivatives or their physiologically acceptable salts represented by the following formula, pharmaceutical compositions comprising the same, and uses thereof. The 13,13a-dihydroberberine derivatives have an activity of promoting glucose absorption in muscle cells, and the whole animal tests show that the present compounds have effects on improving glucose-tolerance and insulin-resistance, facilitating weight loss, relieving fatty liver and the like. Thus, the present compounds can be used in treating diabetes mellitus, adiposity, fatty liver and complications thereof induced by insulin resistance.
