5096-76-4

Usage

Uses

Used in Pharmaceutical Industry:
3-Chloro-6-pyrrol-1-yl-pyridazine is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a potential candidate for the development of new drugs, particularly in the areas of medicinal chemistry where novel scaffolds are constantly sought after for drug discovery.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Chloro-6-pyrrol-1-yl-pyridazine is utilized as a precursor in the synthesis of agrochemicals. Its reactivity and structural features make it suitable for the development of new pesticides or herbicides, contributing to more effective and targeted crop protection strategies.
Used in Materials Science:
3-Chloro-6-pyrrol-1-yl-pyridazine is employed as a building block in the development of new materials with specific properties. Its incorporation into polymers or other materials can lead to the creation of materials with tailored characteristics for use in various applications, such as sensors, electronic devices, or advanced composites.
Used in Organic Synthesis:
As a versatile intermediate in organic synthesis, 3-Chloro-6-pyrrol-1-yl-pyridazine is used for the preparation of a wide range of organic compounds. Its ability to participate in various chemical reactions, such as nucleophilic substitutions, electrophilic additions, or coupling reactions, makes it a valuable component in the synthesis of complex organic molecules for research and industrial applications.

InChI:InChI=1/C8H6ClN3/c9-7-3-4-8(11-10-7)12-5-1-2-6-12/h1-6H

Upstream product

• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 5469-69-2 6-chloro-pyridazin-3-ylamine 
• 141-30-0 3,6-dichlorpyridazine 
• 109-97-7 pyrrole 

Downstream Products

• 1417455-19-6 methyl 3-[6-(1H-pyrrol-1-yl)pyridazin-3-yl]benzoate 
• 138803-58-4 1-[2-(2-Methoxy-phenoxy)-ethylamino]-3-(6-pyrrol-1-yl-pyridazin-3-yloxy)-propan-2-ol 
• 138803-59-5 1-[2-(4-Fluoro-phenoxy)-ethylamino]-3-(6-pyrrol-1-yl-pyridazin-3-yloxy)-propan-2-ol 
• 138803-57-3 1-(2-Phenoxy-ethylamino)-3-(6-pyrrol-1-yl-pyridazin-3-yloxy)-propan-2-ol 

Relevant academic research and scientific papers

Selective mono-amination of dichlorodiazines

A mild, easy-to-perform, and versatile method for the formation of aminochlorodiazines from reaction of several types of dichlorodiazines (i.e., pyridazines, pyrimidines, and pyrazines) with primary or secondary amines in ethanol in the presence of trieth

An electrochemical nickel-catalyzed arylation of 3-amino-6- chloropyridazines

3-Amino-6-aryl- and 3-amino-6-heteroarylpyridazines have been obtained in generally good yield using a nickel-catalyzed electrochemical cross-coupling between 3-amino-6-chloropyridazines and aryl or heteroaryl halides at room temperature. Comparative experiments involving classical palladium-catalyzed reactions, such as Suzuki, Stille, or Negishi cross-couplings, reveal that the electrochemical method can constitute a reliable alternative tool for biaryl formation. A possible reaction mechanism is proposed on the basis of electrochemical analyses.

Synthesis and antihypertensive activity of new 6-heteroaryl-3-hydrazinopyridazine derivatives

The synthesis and pharmacological activity of new 6-heteroaryl-3-hydrazinopyridazines with antihypertensive action are described. The introduction of pyrrole, pyrazole, imidazole, triazole, tetrazole, thiophene, indole, and carbazole heterocyclic rings into the 6 position of the pyridazine nucleus has been carried out by three different methods of synthesis. The hypotensive action has been examined on normotensive and spontaneously hypertensive rats by comparison with dihydralazine (I). 6-Imidazol-1-yl derivatives have proved particularly active. Of these derivatives 3-hydrazino-6-(2-methylimidazol-1-yl)pyridazine (7c) achieves 4.9 times the activity of dihydralazine when administered orally to spontaneously hypertensive rats. The LD50 values of 7c and dihydralazine are very similar.