50986-84-0

Upstream product

• 825-83-2 4-trifluoromethylbenzenethiol 
• 18715-45-2 4-trifluoromethylphenyl disulfide 
• 402-43-7 p-trifluoromethylphenyl bromide 

Downstream Products

• 1026629-55-9 4-Trifluoromethyl-benzenesulfinyl isocyanate 
• 233751-98-9 4-Trifluoromethyl-benzenesulfinic acid ((R)-2-methyl-1-trimethylsilanyloxymethyl-propyl)-amide 
• 829-70-9 4-(trifluoromethyl)benzenesulfinic acid 
• 1026288-18-5 C₁₄H₉Cl₂F₃N₂O₂S 
• 187342-51-4 C₁₄H₁₀ClF₃N₂O₂S 
• 233752-03-9 C₁₉H₃₂F₃NO₂SSi 
• 233752-02-8 C₁₃H₁₈F₃NO₂S 
• 233752-01-7 C₁₃H₁₈F₃NO₂S 
• 233751-99-0 4-Trifluoromethyl-benzenesulfinic acid ((R)-1-hydroxymethyl-2-methyl-propyl)-amide 
• 233752-00-6 4-isopropyl-2-(4-trifluoromethyl-phenyl)-4H,5H-2λ⁴-[1,2,3]oxathiazole 2-oxide 

Relevant academic research and scientific papers

Sulfoxide ligand metal catalyzed oxidation of olefins

The enantioselective synthesis of isochroman motifs has been accomplished via Pd(II)-catalyzed allylic C—H oxidation from terminal olefin precursors. Critical to the success of this goal was the development and utilization of a novel chiral aryl sulfoxide-oxazoline (ArSOX) ligand. The allylic C—H oxidation reaction proceeds with the broadest scope and highest levels asymmetric induction reported to date (avg. 92% ee, 13 examples ≥90% ee). Additionally, C(sp3)-N fragment coupling reaction between abundant terminal olefins and N-triflyl protected aliphatic and aromatic amines via Pd(II)/sulfoxide (SOX) catalyzed intermolecular allylic C—H amination is disclosed. A range of 52 allylic amines are furnished in good yields (avg. 76%) and excellent regio- and stereoselectivity (avg. >20:1 linear:branched, >20:1 E:Z). For the first time, a variety of singly activated aromatic and aliphatic nitrogen nucleophiles, including ones with stereochemical elements, can be used in fragment coupling stiochiometries for intermolecular C—H amination reactions.

Enantioselective Allylic C?H Oxidation of Terminal Olefins to Isochromans by Palladium(II)/Chiral Sulfoxide Catalysis

The enantioselective synthesis of isochroman motifs has been accomplished by palladium(II)-catalyzed allylic C?H oxidation from terminal olefin precursors. Critical to the success of this goal was the development and utilization of a novel chiral aryl sul

C2-symmetric chiral disulfoxide ligands in rhodium-catalyzed 1,4-addition: From ligand synthesis to the enantioselection pathway

A family of chiral C2-symmetric disulfoxide ligands possessing biaryl atropisomeric backbones has been synthesized by using the Andersen methodology. Complete characterization includes X-ray crystallographic studies of all ligands and some of t

Metallated 2-alkenyl sulfoximines in asymmetric synthesis: Regio- and stereoselective synthesis of highly substituted oxabicyclic ethers and studies towards the total syntheses of the euglobals G1 and G2 and arenaran A

2-Cyclopentenyl- and 2-cyclohexenylmethyl sulfoximines can be converted into angular carbon-functionalised, highly substituted, isomerically pure (ds ± 98%) 2-oxabicyclo[3.3.0]octanes and 2-oxabicyclo[3.4.0]nonanes in high yields by a convenient one-pot sequence. Molecular frameworks such as these can be found in many biologically active natural products. In addition to the methodological work, we report on studies towards the total synthesis of the euglobals G1 and G2 and arenaran A.