509953-48-4

Upstream product

• 352-13-6 4-flourophenylmagnesium bromide 
• 85908-96-9 2-oxopiperidine-1-carboxylic acid tert-butyl ester 
• 5414-21-1 5-bromopentan-1-nitrile 
• 1493-23-8 (4-fluorophenyl)lithium 
• 1020718-53-9 C₁₆H₂₂FNO₃ 
• 675-20-7 piperidin-2-one 
• 161564-43-8 2-oxopiperidone-1-carbaldehyde diethyl acetal 
• 460-00-4 1-Bromo-4-fluorobenzene 

Downstream Products

• 1187468-22-9 (S)-2-(4-fluorophenyl)piperidine 
• 1187468-21-8 (R)-2-(4-fluorophenyl)piperidine 

Relevant academic research and scientific papers

Intramolecular Cyclization of Brominated Oxime Ether Promoted with Ytterbium(0) to the Synthesis of Cyclic Imines

The first utility of ytterbium(0) as a mediating-metal in the intramolecular cyclization of brominated oxime ether was reported in this paper. In contrast to the prior methods, the N–O bond was used as a receptor of nucleophilic reagent, rather than as a source of N-centered radicals. Cyclic imines were obtained in this one-pot reaction with a broad scope of substrates and feasible reaction conditions.

Preparation method of imine compound

The invention discloses a preparation method of an imine compound. The method comprises the following steps: under the anhydrous and anaerobic conditions, an oxime ether and a metal element are addedinto a reaction vessel in one pot, tetrahydrofuran is us

Synthesis and kinetic resolution of N-Boc-2-arylpiperidines

The chiral base n-BuLi/(-)-sparteine or n-BuLi/(+)-sparteine surrogate promotes kinetic resolution of N-Boc-2-arylpiperidines by asymmetric deprotonation. The enantioenriched starting material was recovered with yields 39-48% and ers up to 97:3. On lithiation then electrophilic quench, 2,2-disubstituted piperidines were obtained with excellent yields and enantioselectivities.

GAMMA SECRETASE MODULATORS

In its many embodiments, the present invention provides a novel class of heterocyclic compounds as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the central nervous system using such compounds or pharmaceutical compositions.