509953-53-1Relevant academic research and scientific papers
Synthesis of imidazo[4,5-b]pyridines and imidazo[4,5-b]pyrazines by palladium catalyzed amidation of 2-chloro-3-amino-heterocycles
Rosenberg, Adam J.,Zhao, Jinbo,Clark, Daniel A.
supporting information; experimental part, p. 1764 - 1767 (2012/05/20)
A facile synthesis of imidazo[4,5-b]pyridines and-pyrazines is described using a Pd-catalyzed amide coupling reaction. This reaction provides quick access to products with substitution at N1 and C2. A model system relevant to the natural product pentosidi
Synthetic studies on 3-arylquinazolin-4-ones: Intramolecular nucleophilic aromatic substitution reaction of 2-carboxamido-3-arylquinazolin-4-ones and its application to the synthesis of secondary aryl amines
Fuwa, Haruhiko,Kobayashi, Toshitake,Tokitoh, Takashi,Torii, Yukiko,Natsugari, Hideaki
, p. 4297 - 4312 (2007/10/03)
The general synthesis and a novel intramolecular nucleophilic aromatic substitution (SNAr) reaction of 2-carboxamido-3-arylquinazolin-4- ones, a potentially useful scaffold in the field of medicinal chemistry, are described. The synthetic utili
Selective palladium-catalyzed aminations on 2-chloro-3-iodo- and 2-chloro-5-iodopyridine
Maes, Bert U. W.,Loones, Kristof T. J.,Jonckers, Tim H. M.,Lemière, Guy L. F.,Dommisse, Roger A.,Haemers, Achiel
, p. 1995 - 1998 (2007/10/03)
Regioselective palladium-catalyzed aminations with anilines on 2-chloro-3-iodo- and 2-chloro-5-iodopyridine have been performed with excellent yields and good selectivity. The use of a large excess of Cs2CO3 in combination with Pd-BINAP catalyst was essential to obtain sufficiently fast reactions. The mild conditions permit the presence of base sensitive functional groups. Moreover, the catalytic system developed also allows the arylamination of aryl iodides.
