51-31-0

Usage

Uses

Used in Pharmaceutical Industry:
Levisoprenaline is used as a bronchodilator for the treatment of asthma and other respiratory conditions. It helps to relax the muscles in the airways, providing relief from shortness of breath and wheezing.
Used in Cardiology:
Levisoprenaline is used as a medication to treat certain heart conditions, such as congestive heart failure and arrhythmias. It works by stimulating the heart and increasing the force of its contractions, which can help improve blood circulation and overall heart function.
Used in Emergency Medicine:
Levisoprenaline is used as an emergency treatment for severe allergic reactions, also known as anaphylaxis. It helps to counteract the effects of histamine released during an allergic reaction, reducing symptoms such as swelling, difficulty breathing, and low blood pressure.
Used in Ophthalmology:
Levisoprenaline is used as a miotic agent in the treatment of open-angle glaucoma and other eye conditions. It works by constricting the pupil and reducing the production of aqueous humor, which can help to lower intraocular pressure and prevent optic nerve damage.

InChI:InChI=1/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3/t11-/m0/s1

Upstream product

• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 61693-05-8 (R)-(-)-2-amino-1-(3,4-dimethoxyphenyl)ethanol 
• 833353-09-6 (R)-toluene-4-sulfonic acid 2-(3,4-dimethoxyphenyl)-2-hydroxyethyl ester 
• 833353-17-6 (R)-1-(3,4-dimethoxyphenyl)-2-iodo-ethanol 
• 326491-79-6 (R)-2-hydroxy-1-(3,4-dimethoxyphenyl)ethanol 
• 6380-23-0 3,4-dimethoxystyrene 
• 217813-70-2 (R)-(-)-1-(3,4-dimethoxyphenyl)-2-(isopropylamino)ethanol 
• 7683-59-2 isoproterenol 
• 128253-45-2 [(R)-2-(2,2-Diisopropyl-benzo[1,3,2]dioxasilol-5-yl)-2-triethylsilanyloxy-ethyl]-isopropyl-amine 
• 128253-44-1 5-((R)-2-Iodo-1-triethylsilanyloxy-ethyl)-2,2-diisopropyl-benzo[1,3,2]dioxasilole 
• 128253-41-8 2-Chloro-1-(2,2-diisopropyl-benzo[1,3,2]dioxasilol-5-yl)-ethanone 
• 128253-43-0 (R)-1-(2,2-Diisopropyl-benzo[1,3,2]dioxasilol-5-yl)-2-iodo-ethanol 
• 128253-42-9 (R)-2-Chloro-1-(2,2-diisopropyl-benzo[1,3,2]dioxasilol-5-yl)-ethanol 
• 99-40-1 2-chloro-3',4'-dihydroxyacetophenone 

Relevant academic research and scientific papers

The first enantioselective syntheses of pure R- and S-isoproterenol

An efficient and highly selective synthetic route to either R- or S-isoproterenol (1) is described which employs a robot-like catalytic molecule to establish chirality, and readily provides these important therapeutic agents in enantiomerically pure form.

In-situ and one-step preparation of protein film in capillary column for open tubular capillary electrochromatography enantioseparation

In this work, the phase-transitioned BSA (PTB) film using the mild and fast fabrication process adhered to the capillary inner wall uniformly, and the fabricated PTB film-coated capillary column was applied to realize open tubular capillary electrochromatography (OT-CEC) enantioseparation. The enantioseparation ability of PTB film-coated capillary was evaluated with eight pairs of chiral analytes including drugs and neurotransmitters, all achieving good resolution and symmetrical peak shape. For three consecutive runs, the relative standard deviations (RSD) of migration time for intra-day, inter-day, and column-to-column repeatability were in the range of 0.3%–3.5%, 0.2%–4.9% and 2.1%–7.7%, respectively. Moreover, the PTB film-coated capillary column ran continuously over 300 times with high separation efficiency. Therefore, the coating method based on BSA self-assembly supramolecular film can be extended to the preparation of other proteinaceous capillary columns.

Chiral Cr(III)-salen complex embedded over sulfonic acid functionalized mesoporous SBA-15 material as an efficient catalyst for the asymmetric Henry reaction

Designing novel catalytic system for efficient synthesis of enantiomerically pure β-hydroxy nitroalkanes is a challenging area of research. Herein, we have designed a chiral heterogeneous catalyst through the successful loading of chiral Cr(III)-salen com

Chiral copper-salen complex grafted over functionalized mesoporous silica as an efficient catalyst for asymmetric Henry reactions and synthesis of the potent drug (R)-isoproterenol

Synthesis of enantiomerically pure drug molecules using functionalized mesoporous materials bearing a chiral moiety is a longstanding goal in heterogeneous catalysis. Herein, we report an efficient and enantioselective one-pot Henry reaction over a highly

Effect of basic and acidic additives on the separation of some basic drug enantiomers on polysaccharide-based chiral columns with acetonitrile as mobile phase

The separation of enantiomers of 16 basic drugs was studied using polysaccharide-based chiral selectors and acetonitrile as mobile phase with emphasis on the role of basic and acidic additives on the separation and elution order of enantiomers. Out of the studied chiral selectors, amylose phenylcarbamate-based ones more often showed a chiral recognition ability compared to cellulose phenylcarbamate derivatives. An interesting effect was observed with formic acid as additive on enantiomer resolution and enantiomer elution order for some basic drugs. Thus, for instance, the enantioseparation of several β-blockers (atenolol, sotalol, toliprolol) improved not only by the addition of a more conventional basic additive to the mobile phase, but also by the addition of an acidic additive. Moreover, an opposite elution order of enantiomers was observed depending on the nature of the additive (basic or acidic) in the mobile phase.

Asymmetric dihydroxylation route to (R)-isoprenaline, (R)-norfluoxetine and (R)-fluoxetine

An efficient asymmetric synthesis of enantiomerically pure (R)-isoprenaline, (R)-norfluoxetine and (R)-fluoxetine is described using Sharpless asymmetric dihydroxylation as the key step.

Application of cyclam-capped β-cyclodextrin-bonded silica particles as a chiral stationary phase in capillary electrochromatography for enantiomeric separations

Two novel types of substituted cyclam-capped β-cyclodextrin (β-CD)-bonded silica particles have been prepared and used as chiral stationary phases in capillary electrochromatography (CEC). The two stationary phases have a chiral selector with three recognition sites: β-CD, cyclam, and the latter's sidearm. They exhibit excellent enantioselectivities in CEC for a wide range of compounds as a result of the cooperative functioning of the anchored β-CD and cyclam. After inclusion of the metal ion (Ni2+) from the running buffer into the substituted cyclams and their sidearm ligands, the bonded stationary phases become positively charged and can provide extra electrostatic interactions with ionizable solutes and enhance the dipolar interactions with some polar neutral solutes. This enhances the host-guest interaction with some solutes and improves chiral recognition and enantioselectivity. These new types of stationary phases exhibit great potential for fast chiral separations in CEC.

Scavenger assisted combinatorial process for preparing libraries of amides, carbamates and sulfonamides

This invention relates to a novel solution phase process for the preparation of amide, carbamate, and sulfonamide combinatorial libraries. These libraries have utility for drug discovery and are used to form wellplate components of novel assay kits.