510-25-8

Basic information

• Product Name: BELLADONNA TOTAL ALKALOIDS
• Synonyms: 1,2,3,4-Tetrahydro-1-phenyl-1,4-naphthalenedicarboxylic acid bis[(1S,5R)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl];1,2,3,4-Tetrahydro-1-phenyl-1,4-naphthalenedicarboxylic acid bis[(1S,5R)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl] ester;Ditropyl isatropate;Isatropylditropeine;Tropyl isotropate;1,4-Naphthalenedicarboxylic acid, 1,2,3,4-tetrahydro-1-phenyl-, bis(8-methyl-8-azabicyclo(3.2.1)oct-3-yl) ester;1Alphah,5alphah-tropan-3alpha-ol, 1,2,3,4-tetrahydro-1-phenyl-1,4-naphthalenedicarboxylate (2:1) (ester);1-Phenyltetralin-1,4-dicarbonsaeure-di-tropylester
• CAS NO: 510-25-8
• Molecular Formula: C₃₄H₄₂N₂O₄
• Molecular Weight: 542.71
• EINECS: 227-550-6
• Mol File: 510-25-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 129°
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.24g/cm³
• Refractive Index: 1.627
• CAS DataBase Reference: BELLADONNA TOTAL ALKALOIDS(CAS DataBase Reference)
• NIST Chemistry Reference: BELLADONNA TOTAL ALKALOIDS(510-25-8)
• EPA Substance Registry System: BELLADONNA TOTAL ALKALOIDS(510-25-8)

Safety Data

• Hazardous Substances Data: 510-25-8(Hazardous Substances Data)

Usage

General Description

Belladonna Total Alkaloids are naturally occurring chemical compounds composed of various alkaloids found in the Belladonna plant. Key components include atropine, scopolamine, and hyoscyamine. These substances have long been used for their medicinal properties, particularly for their anticholinergic effects. They have a range of applications such as reducing bodily secretions, relaxing smooth muscles and dilating pupils. However, they can potentially be toxic, even lethal, in high doses, causing effects like hallucinations, convulsions, heart problems and other severe reactions.

InChI:InChI=1/C34H42N2O4/c1-35-23-12-13-24(35)19-27(18-23)39-32(37)30-16-17-34(22-8-4-3-5-9-22,31-11-7-6-10-29(30)31)33(38)40-28-20-25-14-15-26(21-28)36(25)2/h3-11,23-28,30H,12-21H2,1-2H3/t23?,24?,25?,26?,27?,28?,30-,34-/m0/s1

Upstream product

• 2292-08-2 tropine hydrochloride 
• 14054-31-0 2-phenyl-acrylic acid tropan-3-yl ester 
• 51-55-8 Atropine 
• 7647-01-0 hydrogenchloride 
• 7664-93-9 sulfuric acid 
• 101-31-5 Hyoscyamine 
• 55-48-1 (1R,3r,5S)-3-tropoyloxytropanium sulfate 
• 55-48-1 atropine sulphate 
• 101716-26-1 (+/-)-1-phenyl-1,2,3,4-tetrahydro-naphthalene-1r,4t-dicarbonyl chloride 

Downstream Products

• 2292-11-7 3exo-bromo-tropane 
• 492-38-6 2-phenylacrylic acid 
• 7432-10-2 Tropanol 

Relevant articles and documents

On the analytics and the stability of atropine sulphate and scopolamine hydrobromide. III. Studies on the stability of tropane alkaloids; Part 80: Contributions to problems concerning the use of plastic containers for liquid pharmaceuticals

On evaluating their investigations, the authors discuss the degradation mechanism of tropane alkaloids in aqueous solution. As evidenced by competitive and consecutive reactions (hydrolysis, dehydration, dimerization), the degradation mechanism is characterized by a complicated course. Apart from temperature, a series of other factors, above all the pH value, exerts a considerable effect on the stability of both the alkaloids. Unbuffered solutions are more stable than buffered ones. The isothermal short-time test is not suitable for stability prediction. In the long-time test it was found that unbuffered aqueous atropine sulphate solutions still contained 90% of their initial drug content after 18 months' storage in low-density polyethylene containers at 20° C. Scopolamine hydrobromide solutions showed an almost analogous behavior. Of the container materials tested, low-density polyethylene bottles have been found to be best suited.