510-25-8 Usage
Uses
Used in Pharmaceutical Industry:
Belladonna Total Alkaloids are used as active pharmaceutical ingredients for their ability to reduce bodily secretions, relax smooth muscles, and dilate pupils. They are particularly effective in treating conditions that involve excessive secretions, such as peptic ulcers, bronchial asthma, and whooping cough.
Used in Ophthalmology:
In the field of ophthalmology, Belladonna Total Alkaloids are used as mydriatics to dilate the pupils. This is beneficial in various diagnostic procedures and in the treatment of certain eye conditions, such as iritis and uveitis, where dilation of the pupil is necessary to prevent adhesions and facilitate the examination of the retina.
Used in Anesthesia:
Belladonna Total Alkaloids are also used in the practice of anesthesia, where they can help to reduce secretions and provide smooth muscle relaxation. This can be particularly useful in procedures that require a clear airway and minimal interference from involuntary muscle contractions.
Used in Homeopathic Medicine:
In homeopathic medicine, Belladonna Total Alkaloids are used in highly diluted forms to treat a variety of conditions, including fever, headache, and inflammation. The homeopathic approach relies on the principle of "like cures like," where the same substance that causes symptoms in a healthy person is used to treat similar symptoms in a sick person, albeit in a highly diluted form.
It is crucial to emphasize that the use of Belladonna Total Alkaloids must be strictly regulated and monitored due to their potential toxicity. Medical professionals must ensure that the dosage is appropriate and that patients are aware of the risks associated with their use.
Check Digit Verification of cas no
The CAS Registry Mumber 510-25-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,1 and 0 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 510-25:
(5*5)+(4*1)+(3*0)+(2*2)+(1*5)=38
38 % 10 = 8
So 510-25-8 is a valid CAS Registry Number.
InChI:InChI=1/C34H42N2O4/c1-35-23-12-13-24(35)19-27(18-23)39-32(37)30-16-17-34(22-8-4-3-5-9-22,31-11-7-6-10-29(30)31)33(38)40-28-20-25-14-15-26(21-28)36(25)2/h3-11,23-28,30H,12-21H2,1-2H3/t23?,24?,25?,26?,27?,28?,30-,34-/m0/s1
510-25-8Relevant academic research and scientific papers
On the analytics and the stability of atropine sulphate and scopolamine hydrobromide. III. Studies on the stability of tropane alkaloids; Part 80: Contributions to problems concerning the use of plastic containers for liquid pharmaceuticals
Jira Th.,Pohloudek Fabini
, p. 520 - 523 (2007/10/02)
On evaluating their investigations, the authors discuss the degradation mechanism of tropane alkaloids in aqueous solution. As evidenced by competitive and consecutive reactions (hydrolysis, dehydration, dimerization), the degradation mechanism is characterized by a complicated course. Apart from temperature, a series of other factors, above all the pH value, exerts a considerable effect on the stability of both the alkaloids. Unbuffered solutions are more stable than buffered ones. The isothermal short-time test is not suitable for stability prediction. In the long-time test it was found that unbuffered aqueous atropine sulphate solutions still contained 90% of their initial drug content after 18 months' storage in low-density polyethylene containers at 20° C. Scopolamine hydrobromide solutions showed an almost analogous behavior. Of the container materials tested, low-density polyethylene bottles have been found to be best suited.
Analysis and stability of atropine sulfate and scopolamine hydrobromide. 1. Qualitative detection of alkaloids in the presence of their decomposition products. 73. Contribution to the problem of the use of plastic receptacles for liquid pharmaceuticals
Jira,Pohloudek-Fabini
, p. 645 - 649 (2007/10/02)
The authors deal with the qualitative determination of tropane alkaloid salts (atropine sulphate and scopolamine hydrobromide) in aqueous solutions in the presence of their decomposition products using thin-layer chromatography. Aqueous solutions of these tropane alkaloid salts were tested for stability after storage in glass and polyethylene containers under various conditions (pH value, temperature, ultra-violet irradiation, oxidative effects). Besides tropine, apoatropine, alpha- and beta-belladonine, further decomposition products showing a basic reaction (and in part not yet identified) were detected. The stability of solid atropine sulphate was studied by means of differential thermal analysis and mass spectrometry.
