5100-21-0Relevant articles and documents
Synthesis of N-(Hetero)aryl Carbamates via CuI/MNAO Catalyzed Cross-Coupling of (Hetero)aryl Halides with Potassium Cyanate in Alcohols
Kumar, S. Vijay,Ma, Dawei
, p. 2706 - 2713 (2018/03/09)
An efficient route to N-(hetero)aryl carbamates was developed through CuI/MNAO [2-((2-methylnaphthalen-1-yl)amino)-2-oxoacetic acid] catalyzed cross-coupling of (hetero)aryl chlorides with potassium cyanate in alcohols at 120-130 °C. This method utilizes
N-(4-ethoxy carbonyl phenyl)-N '-methyl-N' green-phenyl formamidine process for preparing (by machine translation)
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, (2016/12/01)
The invention discloses a N-(4-ethoxy carbonyl phenyl)-N '-methyl-N' green-phenyl formamidine preparation process, it is first by the P-nitro-benzoic acid by esterification reaction and catalytic hydrogenation reaction of the P-aminobenzoic acid ethyl ester is prepared, and then the P-amino-benzoic acid ethyl ester is prepared by two-step condensation reaction; the esterification reaction of the ethanol as the recovery processing ethanol; the recovery processing ethanol is the condensation reaction to produce ethanol obtained by recovery processing after being collected. The technique of the invention the condensation reaction to produce ethanol of recovery processing is used for the esterification reaction, not only reduces production cost, and reduce the pollution of the environment, it is a kind of green preparation process, in particular after the recovery processing by the invention with commercial anhydrous ethanol ethanol compared with almost no influence to the esterification effect. (by machine translation)
Installation of protected ammonia equivalents onto aromatic & heteroaromatic rings in water enabled by micellar catalysis
Isley, Nicholas A.,Dobarco, Sebastian,Lipshutz, Bruce H.
supporting information, p. 1480 - 1488 (2014/03/21)
A single set of conditions consisting of a palladium catalyst, a commercially available ligand, and a base, allow for several types of C-N bond constructions to be conducted in water with the aid of a commercially available "designer" surfactant (TPGS-750-M). Products containing a protected NH2 group in the form of a carbamate, sulfonamide, or urea can be fashioned starting with aryl or heteroaryl bromides, iodides, and in some cases, chlorides, as substrates. Reaction temperatures are in the range of room temperature to, at most, 50 °C, and result in essentially full conversion and good isolated yields.
The Azirine/Oxazolone Method in Peptide Chemistry: Synthesis of Tripeptide Models
Wipf, Peter,Heimgartner, Heinz
, p. 140 - 154 (2007/10/02)
Tripeptides 5, containing an α,α-disubstituted α-amino acid and ethyl p-aminobenzoate, were synthesized in high yield by application of the azirine/oxazolone method (Table 2).In this versatile approach for the incorporation of disubstituted residues into the peptide chain, N-protected peptides or amino acids are coupled with 2,2-dialkyl-3-amino-2H-azirines and, after the selective hydrolysis of the newly formed C-terminal amid bond, further condensed with amino components via in situ generated oxazole-5(4H)-ones in the presence of additives (Scheme 1).A comparison with conventional procedures clearly demonstrates the advantages of this new method that works equally well with β-branched, cyclic, or acyclic disubstituted amino acids.
