51005-86-8

Upstream product

• 81758-04-5 kopeolin 
• 1566571-20-7 7-(((E)-5-((1R,3R,6R)-3-hydroxy-6-(methoxymethoxy)-2,2,6-trimethylcyclohexyl)-3-methylpent-2-en-1-yl)oxy)-2H-chromen-2-one 
• 1566571-19-4 (E)-7-((5-((1R,3R,6R)-3-((tert-butyldimethylsilyl)oxy)-6-(methoxymethoxy)-2,2,6-trimethylcyclohexyl)-3-methylpent-2-en-1-yl)oxy)-2H-chromen-2-one 
• 81758-04-5 7-{5-[(1R,6S)-6-hydroxy-2,2,6-trimethyl-3-oxocyclohexyl]-3-methylpent-2-enyloxy}chromen-2-one 

Downstream Products

• 512-17-4 (-)-farnesiferol C 
• 532-15-0 farnesiferol B 
• 54352-98-6 kopetdaghin 
• 81800-58-0 lehmferin 
• 81758-04-5 7-{5-[(1R,6S)-6-hydroxy-2,2,6-trimethyl-3-oxocyclohexyl]-3-methylpent-2-enyloxy}chromen-2-one 
• 81758-04-5 kopeolin 

Relevant academic research and scientific papers

Enantioselective syntheses of the proposed structures of kopeolin and kopeolone

The first total syntheses of the proposed structures of kopeolin (1) and kopeolone (3) have been achieved from a common enantiopure chiral building block obtained by a chemoenzymatic enantioconvergent methodology. The syntheses feature two key steps: a on

Revised structure, total synthesis, and absolute configuration of kopeolin and kopeolone

An enantioselective total synthesis of two sesquiterpenoids, kopeolin and kopeolone, has been achieved. Using the diastereoselective addition of an organocerate as a key step, we controlled the absolute stereochemistry of a crucial stereocenter present in these natural products. This approach allowed us to confirm a structural revision that we previously proposed (Chem. - Eur. J. 2013, 19, 10632-10642) and to fully characterize these natural products while elucidating their absolute stereochemistry.

A NEW TERPENOID COUMARIN FROM Ferula kopetdaghensis

From the roots of Ferula kopetdaghensis Eug.Kor. have been isolated nevskin and isosamarcandin and a new terpenoid coumarin kopeolone, C24H30O5.M(1+) 398, mp 125-126 deg C, D18 +70 deg (c 0.1, ethanol).On the basis of UV, IR, PMR,