81758-04-5Relevant articles and documents
Revised structure, total synthesis, and absolute configuration of kopeolin and kopeolone
Miquet, Stephanie,Bremond, Paul,Ayela, Benjamin,Marque, Sylvain R. A.,Audran, Gerard
, p. 2268 - 2273 (2014/04/03)
An enantioselective total synthesis of two sesquiterpenoids, kopeolin and kopeolone, has been achieved. Using the diastereoselective addition of an organocerate as a key step, we controlled the absolute stereochemistry of a crucial stereocenter present in these natural products. This approach allowed us to confirm a structural revision that we previously proposed (Chem. - Eur. J. 2013, 19, 10632-10642) and to fully characterize these natural products while elucidating their absolute stereochemistry.