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51022-70-9

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51022-70-9 Usage

Description

Albuterol sulfate (Brand name: PROVENTIL? HFA) is the sulfate form of albuterol which is also known as salbutamol. It is a kind of short-acting, selective beta2-adrenergic receptor agonist being capable of opening up the medium and large airways in the lungs. It is mainly used for the treatment of bronchospasm (induced by bronchial asthma or exercise) as well as chronic obstructive pulmonary disease (COPD). Albuterol sulfate takes effects through directly biding to the beta (2)-adrenergic receptors in the lung and causing relaxation of bronchial smooth muscles. This relaxation is mediated by its effect of stimulating cAMP production through activating adenylate cyclase, further inhibiting the phosphorylation of myosin and lowering the intracellular calcium level. Albuterol sulfate can also be used to treat acute hyperkalemia of the blood.

Chemical Properties

Albuterol sulfate is a white or practically white powder, freely soluble in water and slightly soluble in ethanol.

Uses

Albuterol Sulfate belongs to a class of bronchodilator drugs called β2-adrenoceptor agonists. It is a prescription medicine used to treat symptoms of bronchospasm. Albuterol Sulfate may be used alone or with other medications.

Definition

ChEBI: Albuterol sulfate is an ethanolamine sulfate salt. It is functionally related to an albuterol.

Brand name

Accuneb (Dey); Proair (IVAX); Proventil (Schering); Ventolin (GlaxoSmithKline); Volmax (Muro); Vospire (Odyssey).

General Description

Albuterol belongs to the class of medicines known as bronchodilators. It is also called a short-acting beta-agonist (SABA).

Biological Activity

Non-selective β -adrenergic agonist, more potent at β 2 than β 1 receptors.

Veterinary Drugs and Treatments

Albuterol is used principally in dogs and cats for its effects on bronchial smooth muscle to alleviate bronchospasm or cough. It is also used in horses as a bronchodilator.

Mode of action

Albuterol Sulfate is the sulfate salt of the short-acting sympathomimetic agent albuterol, a 1:1 racemic mixture of (R)-albuterol and (S)-albuterol with bronchodilator activity. Albuterol stimulates beta2-adrenergic receptors in the lungs, thereby activating the enzyme adenylate cyclase that catalyzes the conversion of ATP to cyclic-3',5'-adenosine monophosphate (cAMP). Increased cAMP concentrations relax bronchial smooth muscle, relieve bronchospasms, and reduce inflammatory cell mediator release, especially from mast cells. To a lesser extent albuterol stimulates beta1-adrenergic receptors, thereby increasing the force and rate of myocardial contraction.

References

https://en.wikipedia.org/wiki/Salbutamolhttps://www.drugbank.ca/drugs/DB01001http://www.rxlist.com/albuterol-sulfate-drug/indications-dosage.htm

Check Digit Verification of cas no

The CAS Registry Mumber 51022-70-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,0,2 and 2 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 51022-70:
(7*5)+(6*1)+(5*0)+(4*2)+(3*2)+(2*7)+(1*0)=69
69 % 10 = 9
So 51022-70-9 is a valid CAS Registry Number.
InChI:InChI=1/2C12H19NO3.H2O4S/c2*1-12(2,3)13-7-11(16)8-4-5-9(14)10(15)6-8;1-5(2,3)4/h2*4-6,11,13-16H,7H2,1-3H3;(H2,1,2,3,4)

51022-70-9 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (A18544)  Salbutamol sulfate, 99%   

  • 51022-70-9

  • 1g

  • 424.0CNY

  • Detail
  • Alfa Aesar

  • (A18544)  Salbutamol sulfate, 99%   

  • 51022-70-9

  • 5g

  • 1683.0CNY

  • Detail
  • Alfa Aesar

  • (A18544)  Salbutamol sulfate, 99%   

  • 51022-70-9

  • 25g

  • 4067.0CNY

  • Detail
  • Sigma-Aldrich

  • (PHR1053)  Albuterolsulfate  pharmaceutical secondary standard; traceable to USP, PhEur and BP

  • 51022-70-9

  • PHR1053-1G

  • 732.19CNY

  • Detail
  • Sigma-Aldrich

  • (Y0001288)  Salbutamol sulfate for system suitability  European Pharmacopoeia (EP) Reference Standard

  • 51022-70-9

  • Y0001288

  • 1,880.19CNY

  • Detail
  • USP

  • (1012633)  Albuterolsulfate  United States Pharmacopeia (USP) Reference Standard

  • 51022-70-9

  • 1012633-200MG

  • 4,588.74CNY

  • Detail

51022-70-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name Albuterol sulfate

1.2 Other means of identification

Product number -
Other names Mozal

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:51022-70-9 SDS

51022-70-9Upstream product

51022-70-9Relevant articles and documents

Process for the enantiomeric enrichment of salbutamol and salbutamol precursors

-

Page/Page column 10, (2008/06/13)

The present invention relates to a process for the enantiomeric enrichment of salbutamol and salbutamol precursors and the acid-addition salts thereof: where R is hydrogen or benzyl, R' is hydrogen or benzyl and X is CH2OH or COO-C1-C4-alkyl the process comprising the crystallization of a compound of the formula I in the form of its acid-addition salt with an achiral carboxylic acid A that has at least three carbon atoms and a solubility of less than 50 g/l in water at pH 3, 20°C and 1013 mbar, from a solution containing a mixture of the enantiomers of the compound of formula I and the achiral carboxylic acid A in the presence of seed crystals of the desired enantiomer of the compound of formula I or the acid addition salt thereof, whereby the enantiomerically enriched acid-addition salt of the compound of formula I is obtained.

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