51043-64-2Relevant academic research and scientific papers
Quinazoline Antifolates Inhibiting Thymidylate Synthase: Variation of the N10 Substituent
Jones, Terence R.,Calvert, A. Hilary,Jackman, Ann L.,Eakin, M. Allan,Smithers, Michael J.,et al.
, p. 1468 - 1476 (2007/10/02)
The synthesis of 12 new 5,8-dideazafolates with isopropyl, cyclopropylmethyl, 2-fluoroethyl, carbamoylmethyl, phenacyl, 3-fluorobenzyl, 5-uracilylmethyl, carboxymethyl, 2-carboxyethyl, 3-cyanopropyl, 3-hydroxypropyl, and cyanomethyl substituents at N
Folate analogues. 21. Synthesis and antifolate and antitumor activities of N10-(cyanomethyl)-5,8-dideazafolic acid
Nair,Salter,Kisliuk,Gaumont,North,Sirotnak
, p. 605 - 607 (2007/10/02)
A close analogue of the antileukemic agent 5,8-dideaza-N10 propargylfolic acid (2) was synthesized by replacing the propargyl moiety of 2 with a cyanomethyl group. This compound, N10-(cyanomethyl)-5,8-dideazafolic acid (3), was evalu
