51068-75-8Relevant articles and documents
Intramolecular rhodium-catalyzed activation of α-amino C-H bonds: decisive influence of conformational factors in the synthesis of bicyclic aminals from N-sulfamoyloxyacetyl azacycloalkanes
Morin, Marie S.T.,Toumieux, Sylvestre,Compain, Philippe,Peyrat, Sandrine,Kalinowska-Tluscik, Justyna
, p. 8531 - 8535 (2007)
The activation of α-amino C-H bonds in azacycloalkanes by way of intramolecular rhodium-catalyzed amination is reported. In this study, the 'activating' sulfamoyloxy group is attached to the endocyclic nitrogen atom with an appropriate linker. The influence of various structural parameters was studied. Results obtained demonstrate the remarkable conformational control that is possible with such azacycloalkane systems. This work leads to the first example of a successful intramolecular catalyzed amination of a tertiary sulfamic ester, a substrate known to be highly prone to elimination and/or nucleophilic displacement.
Synthesis and evaluation of in vitro anti-tuberculosis activity of N-substituted glycolamides
Daryaee, Fereidoon,Kobarfard, Farzad,Khalaj, Ali,Farnia, Parisa
experimental part, p. 289 - 295 (2009/04/07)
On the basis of the structural similarity of N-substituted glycolamides with N-glycolyl muramic acid residues of the cell wall of Mycobacterium tuberculosis, a series of these compounds were designed and synthesized by the reaction of glycolic acid acetonide 1 (2,2-dimethyl-5-oxo-1,3-dioxolane) with the proper amines. The minimum inhibitory concentration (MIC) was determined against M. tuberculosis H37Rv in BACTEC 12B medium, using the Microplate Alamar Blue Assay (MABA). Among the synthesized compounds, all those with disubstituted amide structure accompanied by one or two heteroatom(s) with loan pair(s) of electrons atom(s) β to the amide nitrogen demonstrated moderate anti-tuberculosis activity and all the monosubstituted amides showed no activity at all.
Kinetic resolution of aliphatic oxiranes mediated by in situ formed molydenum(VI) (oxo-diperoxo) hydroxy acid amide / chiral diol complexes
Schurig, Volker,Betschinger, Frank
, p. 555 - 560 (2007/10/02)
In situ formed molybdenum(VI) (oxo-diperoxo) hydroxy acid amide / chiral diol complexes mediate the efficient kinetic resolution of simple aliphatic oxiranes.This method furnishes high enantiomeric yields of the residual oxirane.The oxidative cleavage of the oxiranes to carbonyl compounds is a non-stoichiometric reaction in the presence of oxygen. oxiranes / kinetic resolution / chiral molybdenum(VI) (oxo-diperoxo) complexes
