51070-68-9

Upstream product

• 62-53-3 aniline 
• 27550-90-9 2-methylmorpholine 
• 108-86-1 bromobenzene 
• 114480-27-2 N-allyl N-(β-hydroxyethyl) aniline 
• 23980-38-3 1-bromo-2-(2-chloro-ethoxy)-propane 

Relevant academic research and scientific papers

Practical Catalytic Cleavage of C(sp3)?C(sp3) Bonds in Amines

The selective cleavage of thermodynamically stable C(sp3)?C(sp3) single bonds is rare compared to their ubiquitous formation. Herein, we describe a general methodology for such transformations using homogeneous copper-based catalysts in the presence of air. The utility of this novel methodology is demonstrated for Cα?Cβ bond scission in >70 amines with excellent functional group tolerance. This transformation establishes tertiary amines as a general synthon for amides and provides valuable possibilities for their scalable functionalization in, for example, natural products and bioactive molecules.

Morpholine derivative oxidation ring-opening method and product thereof

The invention relates to a morpholine derivative oxidation ring-opening method and a product thereof, and belongs to the technical field of compound preparation. The method for promoting oxidative cracking of C (sp3)-C (sp3) bonds of a morpholine derivative by visible light has been successfully developed under the inspiration of the design concept of visible light induced C (sp3)-C (sp3) bond cracking. According to the morpholine derivative oxidation ring-opening method, C (sp3)-C (sp3) bonds without ring stress are cracked by using visible light as an energy source and O2 as a final oxidizing agent, use of transition metal, high temperature, high pressure and chemical equivalent dangerous oxidizing agents is avoided, good functional group tolerance is established, 30 substrates are obtained, the yield is as high as 83%, and a supplementary scheme is provided for realizing oxidative cracking of the morpholine derivative under a mild condition.

Visible-Light-Mediated Aerobic Oxidative C(sp3)?C(sp3) Bond Cleavage of Morpholine Derivatives Using 4CzIPN as a Photocatalyst

Herein, a metal-free strategy for the aerobic oxidative cleavage of the inert C(sp3)?C(sp3) bond was developed. Deconstruction of morpholine derivatives was conducted using visible light as an energy source and O2 as an oxidant under mild conditions. This procedure demonstrated suitable selectivity and functional group tolerance. Moreover, a possible mechanism involving a radical process was proposed based on a series of mechanism exploration and control experiments. (Figure presented.).

SYNTHESE DES MORPHOLINES III. APPLICATION DE LA REACTION D'OXYMERCURATION-DEMERCURATION POUR LA SYNTHESE DES 2-METHYLMORPHOLINES

La cyclisation intramoleculaire de divers 2-allylaminoalcools par la reaction d'oxymercuration-demercuration conduit aux morpholines correspondantes avec de bons rendements.La structure des produits obtenus et la stereochimie de la reaction ont ete etudies par spectrometrie IR et RMN 1H.